Regulation of placentation by the transforming growth factor beta superfamily

EA Adu-Gyamfi, YB Ding, YX Wang - Biology of Reproduction, 2020 - academic.oup.com
… by up-regulating SNAIL-mediated expression and activity of … A, B, and AB facilitates human
trophoblast cell invasion by up-… inhibits trophoblast proliferation by inducing G1 cell cycle …

GATA3 and TGF-β in normal placenta and pre-eclampsia

A Perna, E Hay, A Lucariello, B Scala, P De Blasiis… - Tissue and Cell, 2024 - Elsevier
… Also transforming growth factor beta (TGF-β) plays a … In pre-eclampsia TGF-β inhibits
trophoblast cell invasion during the … epithelial markers and induce mesenchymal markers. These …

[HTML][HTML] GDF15 deficiency hinders human trophoblast invasion to mediate pregnancy loss through downregulating Smad1/5 phosphorylation

YT Zeng, WF Liu, PS Zheng, S Li - Iscience, 2023 - cell.com
… , and anti-Mullerian hormone (AMH) belong to the transforming growth factor (TGF-β)
family. The TGF-… TGF-β1 was proved to inhibit trophoblast cell invasion by inducing Snail-mediated

Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta

S Haider, AI Lackner, B Dietrich… - Proceedings of the …, 2022 - National Acad Sciences
… Inspection of the different trophoblast models revealed that TGF-β inhibition altered cellular
… be critical for the induction of human trophectodermal stem cells from naive pluripotent stem …

[HTML][HTML] The role of TGF-β during pregnancy and pregnancy complications

B Wen, H Liao, W Lin, Z Li, X Ma, Q Xu… - International Journal of …, 2023 - mdpi.com
Transforming growth factor beta (TGF-β) serves as a … that TGF-β also inhibits trophoblast cell
invasion during the first … promotion or inhibition of decidualization, as well as the induction of …

[HTML][HTML] miR-18a contributes to preeclampsia by downregulating Smad2 (full length) and reducing TGF-β signaling

P Xu, Z Li, Y Wang, X Yu, X Shao, Y Li, C Peng… - … Therapy-Nucleic Acids, 2020 - cell.com
inhibition of trophoblast cell invasion by transforming growth factor-β (TGF-β). In conclusion,
our results suggest that miR-18a inhibits … to the enhancement of trophoblast cell invasion. A …

[HTML][HTML] The TGF-β/UCHL5/Smad2 axis contributes to the pathogenesis of placenta accreta

K Hashimoto, Y Miyagawa, S Watanabe… - International Journal of …, 2023 - mdpi.com
… We focused on the transforming growth factor (TGF)-β1-Smad pathway and … cell migration
and invasion in JEG-3 and HTR-8/SVneo cells. Contrary to our expectations, UCHL5 inhibition

VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

DC Sung, X Chen, M Chen, J Yang, S Schultz, A Babu… - Elife, 2022 - elifesciences.org
… Deletion of VE- cadherin in trophoblasts disrupts cell migration resulting in placental and …
Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing Snail- mediated

Expression of ESRP1 at human fetomaternal interface and involvement in trophoblast migration and invasion

J Jia, E Shi, X Zhou, S Zhu, J Li, J Zhang, J Yu, S Wang… - Placenta, 2020 - Elsevier
… , probably through the induction of EMT. To further verify the … by attenuating invasion and
metastasis via the inhibition of … inhibitory proteins such as transforming growth factor-β family …

The transforming growth factor β superfamily as possible biomarkers of preeclampsia: a comprehensive review

EA Adu-Gyamfi, J Lamptey, F Duan… - Biomarkers in …, 2019 - Taylor & Francis
… activin A-induced preeclampsia symptoms in mice, following the inhibition of low molecular
… a reduction in nodal expression to augment trophoblast invasion [Citation103]. Conversely, …