… , as oxygen affinity, tetramer stability, oxidation state and … oxygen carriers (HBOCs), protein
therapeutics intended to deliver oxygen to tissues as an alternative to RBC transfusions for “…

… , or delaying the need for allogeneic red cell transfusion in these patients. Hemopure was
tested in the United States for a similar indication in orthopedic surgical patients (14, 15) . …

… The clinical benefits of blood substitutes/oxygen therapeutics … ” (Fe 2+ ) state; it is unable to
bind oxygen if the hemoglobin … Instead of looking for an agent comparable to RBC transfusion…

… transfusion, neither chemical-based products such as perfluorocarbons nor hemoglobin-based
oxygen carriers … an artificial oxygen carrier that may infer a morbidity or mortality benefit to …

… oxygen carriers (HBOCs), which are anticipated for use as biomaterials that have potential to
resolve issues of transfusion by … would be useful by anyone, supporting rapid transfusion in-…

… transfusion is still an unmet need of modern society. More than 50 years of research on
acellular hemoglobin (Hb)-based oxygen carriers … must occur at a high affinity for the O 2 state to …

… transfusion, and possible transmission of pathogens through blood. Hemoglobin-based
oxygen carriers (HBOCs) are a class of soluble nano-oxygen carriers prepared by chemical …

… as oxygen carriers have been developed over the years to address the clinical needs not
currently met by transfusions … the T state, thus contributing to the release of more oxygen to the …

… in the united states, it is estimated that approximately 11 … rbcs for transfusion medicine
hemoglobin (hb)Ybased o2 carriers (… that the o2 carrying capacity is a secondary benefit of polyhb …

… Blood transfusion risks in addition to the diminishing supply of … with carbodiimide at the
carboxyl groups. This causes the … regarding survival benefits: early replacement of oxygen-…