… Using genetically engineered pigs for the organ shortage is … , which could limit the expression
of CTLA4-Ig to specific tissues … pigs were bred to specifically express CTLA4-Ig in neurons […

… time of neurons from CTLA4-Ig modified pigs reached 549 days after xenotransplantation
(… In xenotransplantation, the soluble HLA-G can protect porcine endothelial cells from NK cell…

… to the success of xenotransplantation [5]. … CTLA4-Ig, have not been fully tested in nonhuman
primates transplanted with grafts from TKO pigs expressing numerous human transgenes…

… Therefore, transgenic pig expression of hCTLA4-Ig is a potential means of preventing T-cell
activity. Martin et al. produced transgenic pigs with neuronal expression of hCTLA4-Ig and …

… Transgenic expression of HLA-G1 gene also shows inhibitory activities in … Pig xenoislet
survival was increased by CTLA4 Ig or anti-CD40L treatment, even though CD4 + T cells display …

… Porcine islet cell xenotransplantation has been investigated … with unilateral transplantation
of fetal pig neural cells into the … the opposite action of CTLA4-Ig derivative is currently used in …

… human CTLA4-Ig expression on porcine cells and tissues were shown in xenogeneic neuronal
… Therefore, we generated transgenic pigs expressing human thrombomodulin under the …

… Survival has been even longer for islets or neurons which is less challenging than the …
plus local production of CTLA4-Ig to control rejection of transgenic pig neuroblasts in non-human …

… donor for xenotransplantation. … CTLA4-Ig (hCTLA4-Ig) into the porcine genome may alleviate
T cell response in xenografts. It was shown that neuronal expression of hCTLA4-Ig in pigs …

… hurdles facing pig-toprimate cell and tissue xenotransplantation and … fetal pig islets. Recent
comparison of N-glycan moieties of … human CTLA4-Ig under the control of a neuronspecific …