… Recent improvements in outcomes for patients with PAH reflect a move to the use of
combination drug therapy targeting multiple pathways. An overview of clinical trials of combination …

… and management of pulmonary arterial hypertension (PAH) includes several advances, …
of extrapulmonary vascular organ system involvement, validated point-of-care clinical …

… December 30, 2021, using search terms for pulmonary arterial hypertension. Articles were
selected for inclusion based on relevance to current clinical practice. Randomized clinical …

… new challenges in clinical care and future drug development … important to incorporate into
future studies. Novel biomarkers … may halt the surge of new development by committing study …

… Pulmonary arterial hypertension (PAH) leads to progressive increases in pulmonary vascular
… and discuss recent updates in the classification and management of patients with PAH. …

… Given the rare nature of pulmonary arterial hypertension and low number of patients … the
progress in pulmonary arterial hypertension clinical trials and identify future opportunities for …

… Looking to the future, we strongly encourage the translation of basic discovery into safe
and effective new therapies, through the conduct of well-designed clinical trials. …

… receiving background therapy for pulmonary arterial hypertension to … , and this would be
important to address in future trials. … trial, treatment with sotatercept reduced pulmonary vascular …

… heritable pulmonary arterial hypertension. Regarding the … methods, treatment methods,
prognosis, and future perspective … Due to recent advances in echocardiography, it is now …

… Recent Advances: Most current research in the PAH field has been focused on the late stage
of the disease, largely due to an urgent need for patient treatment … Future Directions: There …