… Trehalose-6-phosphate phosphatase (TPP) is a key enzyme of the most common trehalose
… attractive target owing to the toxicity of accumulated trehalose-6-phosphate in pathogens. …

… The bacterium Pseudomonas aeruginosa is a leading cause of hospital-acquired infections
… Trehalose 6-phosphate phosphatase (TPP) is an enzyme of the trehalose biosynthesis …

… We report the functional and structural characterization of trehalose-6-phosphate phosphatase
(TPP), from the Gram-negative bacterium B. pseudomallei that causes melioidosis, a …

… where trehalose synthesis is not induced led to growth inhibition and the accumulation of
trehalose‐6‐phosphate. Our results demonstrate that trehalose‐6‐phosphate affects multiple …

… Trehalose for various cell survival and transmission purposes [9]. In Cryptococcus
neoformans, trehalose … Overall, one may conclude that trehalose phosphate phosphatases are …

… Trehalose 6-phosphate (Tre6P), the intermediate of trehalose biosynthesis, is an essential …
proteins that catalyse its degradation, the trehalose 6-phosphate phosphatases (TPPs). Often …

… Pseudomonas aeruginosa is often … trehalose-biosynthetic genes and cellular levels of
trehalose, a disaccharide that protects against environmental stresses. The induction of trehalose …

… The only exception within the panel of bacterial TPPs tested here is the enzyme from
Pseudomonas aeruginosa which was susceptible to inhibition by 1 (Fig. 2) with an apparent K i of …

… specificity of trehalose-6-phosphate phosphatases, there are … In previous studies, some
selected generic phosphatase inhibitors … inhibitors for trehalose 6-phosphate phosphatases. …

… in pathogen growth has been reported in Pseudomonas aeruginosa infection of plants.
Here, … For example, trehalose 6 phosphate has been reported to be an inhibitor of the P. …