Molecular mechanisms of nickel-induced carcinogenesis

YO Son - Endocrine, Metabolic & Immune Disorders-Drug …, 2020 - ingentaconnect.com
… compounds such as nickel sulfide, nickel oxide, nickel sulfite, etc… nickel treatment resulted
in increased methylation of histone … insoluble nickel compounds efficiently transformed culture

[HTML][HTML] Integration of epigenetic mechanisms into non-genotoxic carcinogenicity hazard assessment: Focus on DNA methylation and histone modifications

D Desaulniers, P Vasseur, A Jacobs… - International Journal of …, 2021 - mdpi.com
… Note that spontaneous deamination of 5mC leading to C to T … suppression that concurred
with H2B truncation (a similar … histones H2B and H2A whereas UBCH6 conjugates on H2B. …

[HTML][HTML] Epigenetic regulation in chromium-, nickel-and cadmium-induced carcinogenesis

L Zhao, R Islam, Y Wang, X Zhang, LZ Liu - Cancers, 2022 - mdpi.com
… that catalyze various important oxidative reactions in cells [117]. A key … Ni induced histone
hypoacetylation in Hep3B cells by … out in cultured cells, such as 16HEBs and BEAS-2B cells, or …

[图书][B] A Mechanism Based Probe for Visualising Chromatin-modifying Enzyme Lysine-Specific Histone Demethylase 1

PE Lane - 2021 - search.proquest.com
… Lysine-specific demethylase 1 (LSD1), the first histone demethylase to be identified, catalyses
specifically the demethylation of the mono and dimethyl groups of histone 3 (H3) lysine 4 (…

Expanding the Chromatin Toolbox: Employing Designer Chromatin Substrates to Characterize Histone Ptms and Mutations

BJ Lukasak - 2022 - search.proquest.com
… -mediated monoaminylation of histones and nucleosome asymmetry in chromatin. Using
a biorthogonal labeling strategy, we successfully demonstrated that histones are subject to …

The Role of the Metabolic Enzyme Fumarase in DNA Repair

W Suqing - 2022 - search.proquest.com
… Besides histone H2AX, core histone H2B is also modified … % formaldehyde to 45 ml of cell
culture and shake for 20 minutes. … once with Ni binding buffer and three times with Ni washing …

Targeting the Epigenome as a Therapeutic Strategy for Pancreatic Tumors: DNA and Histone Modifying Enzymes

SK Mungamuri - … Tolerance to Pancreatic Cancer Unresponsiveness to …, 2019 - Elsevier
… SUV39H1/2 inhibition was shown to negatively regulate the PDAC cell growth in cell culture,
… In addition to point mutations, truncations, frameshifts, and amplification of MLL genes have …

[PDF][PDF] Epigenetic Regulation in Chromium-, Nickel-and Cadmium-Induced Carcinogenesis. Cancers 2022, 14, 5768

L Zhao, R Islam, Y Wang, X Zhang, LZ Liu - 2022 - researchgate.net
… that catalyze various important oxidative reactions in cells [117]. … Ni induced histone
hypoacetylation in Hep3B cells by … suspension culture assay, an indicator of the stemness of the …

The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A. W

A Osakabe, B Jamge, E Axelsson, SA Montgomery… - Nature Cell …, 2021 - nature.com
… ligation, oxidation of 5mC and 5hmC, deamination and library … cultured cells were incubated
at 25 C for an additional 12 h. … Cells expressing DDM1 truncations were collected and lysed …

The epigenetic machinery in the life cycle and pharmacoepigenetics

R Cacabelos, I Tellado, P Cacabelos - Pharmacoepigenetics, 2019 - Elsevier
… 5fC is an oxidation product of 5-methylcytosine (5mC), the two … in B cells by catalyzing
deamination and subsequently mutating … The AID truncated form W68X is impaired to interact with …