[HTML][HTML] Natural compounds based chemotherapeutic against Chagas disease and leishmaniasis: Mitochondrion as a strategic target
D Lazarin-Bidóia, FP Garcia… - Memórias do Instituto …, 2022 - SciELO Brasil
… Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of … trypanocidal
action of eupomatenoid-5 could be associated with mitochondrial dysfunction and oxidative …
action of eupomatenoid-5 could be associated with mitochondrial dysfunction and oxidative …
… type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell …
KD Rodríguez-Hernández, I Martínez… - Bioorganic …, 2020 - Elsevier
… We decided to investigate possible oxidative damage caused by mammea A/BA in the
parasites. … The present study found that the trypanocidal effect of mammea A/BA appears to be a …
parasites. … The present study found that the trypanocidal effect of mammea A/BA appears to be a …
The antidepressant clomipramine induces programmed cell death in Leishmania amazonensis through a mitochondrial pathway
JH da Silva Rodrigues, N Miranda, H Volpato… - Parasitology …, 2019 - Springer
… of action, clomipramine led parasites do mitochondrial … induced strong oxidative stress in the
parasites. The … of psychiatric disorders, including obsessive-compulsive disorder. It presents …
parasites. The … of psychiatric disorders, including obsessive-compulsive disorder. It presents …
… effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ …
N Martinez-Sotillo, A Pinto-Martínez, E Hejchman… - Parasitology …, 2019 - Elsevier
… eupomatenoid-5 showed a similar mechanism of action on its trypanocidal action, targeting
the mitochondria … Thus, it was shown that eupomatenoid-5 induces an oxidative stress in the …
the mitochondria … Thus, it was shown that eupomatenoid-5 induces an oxidative stress in the …
Virtual Screening Based on Ligand and Structure with in vitro Assessment of Neolignans against Trypanosoma cruzi
MS Maia, RS Andrade, JMS Sousa… - Journal of the Brazilian …, 2023 - SciELO Brasil
… trypanocidal action of eupomatenoid-5 might be associated with mitochondrial dysfunction
and oxidative damage, which can trigger destructive effects on the biological molecules of T. …
and oxidative damage, which can trigger destructive effects on the biological molecules of T. …
… analogues present effective antileishmanial activity against promastigotes and amastigotes from distinct Leishmania species by multitarget action in the parasites
LMR Antinarelli, RS Meinel, EAF Coelho… - Journal of Pharmacy …, 2019 - academic.oup.com
… effect of AR26 against intramacrophage amastigotes was related with the activation of oxidative
… to AR26, suggesting that this molecule directly acted causing mitochondrial dysfunction. …
… to AR26, suggesting that this molecule directly acted causing mitochondrial dysfunction. …
[HTML][HTML] Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents
F Salgado, M Moncada-Basualto… - Arabian Journal of …, 2021 - Elsevier
… , proposing oxidative stress as a possible trypanocidal mechanism. … action, we reported
variations in the mitochondrial membrane potential, which were directly related to the dysfunction …
variations in the mitochondrial membrane potential, which were directly related to the dysfunction …
[HTML][HTML] Current trends in the pharmacological management of Chagas disease
V Ribeiro, N Dias, T Paiva, L Hagström-Bex… - International Journal for …, 2020 - Elsevier
… diseases, especially for neglected disorders. This repositioning approach is … In addition to
induce mitochondrial changes in the … occidentale showed trypanocide effects similar to those of …
induce mitochondrial changes in the … occidentale showed trypanocide effects similar to those of …
Antiprotozoal Effects of Wild Plants
MS Akram, RZ Abbas, JL Martinez - Ethnopharmacology of Wild …, 2021 - taylorfrancis.com
… Trypanocidal action of eupomatenoid-5 is related to mitochondrion dysfunction and
oxidative damage in Trypanosoma cruzi. Microbes Infect., (12-13): 1018–24. doi: 10.1016/j.micinf.…
oxidative damage in Trypanosoma cruzi. Microbes Infect., (12-13): 1018–24. doi: 10.1016/j.micinf.…
Emerging Phytochemicals to Treat Leishmaniasis: A Review of Experimental Studies from 2011 to 2021
… Eupomatenoid-5, a neolignan extracted from leaves of Piper regnellii var. pallescens, was
shown antileishmanial activity. … and oxidative stress, which leads to mitochondrial dysfunction …
shown antileishmanial activity. … and oxidative stress, which leads to mitochondrial dysfunction …