… pulsatile tubular cardiac tissue using cell sheet based-tissue engineering. First, we fabricated
human induced pluripotent stem cell (hiPSc)-derived cardiomyocyte sheets and normal …

… be fused together to make long tube structures and theoretically cardiac-based rings could
… a TEPC (ΔP) under electrical pacing with 0, 1 and 2 Hz (100 mA current for 10 ms impulse). …

… -derived cardiomyocytes, human umbilical vein endothelial cells, and human fibroblasts.
To … suffering from congenital heart diseases, we constructed scaffold-free tubular EHTs (T-EHTs…

… response, 35 and matured membranous structure formation (T-tubule-like structures). These
3D … width) and a known period between pulses (pulse frequency). The pulse generates an …

… Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) … t-tubule
system in the function of mature cardiac tissue, we postulated that the emergence of a t-tubule …

… Impulse per glucose consumption in the cardiac tissue was calculated as the index of …
hormones promote functional T-tubule development in human-induced pluripotent stem cell-…

… cells focused on single-cells and utilized mixed cell populations. Our goal was to develop
clinically-relevant engineered heart tissues (… Here we show that such EHTs can be generated …

… located in the SA node cause the atrial muscles to contract, sending an impulse through to
the … from the addition of smaller spheroids into a round bottom tube (Figure 1A and 1B) and all …

… of human tubular cardiac tissues derived from … These tubular human cardiac tissues that
can generate pulse pressure in vivo may contribute to the development of a bioengineered heart …

… Induced pluripotent stem cells (iPSCs) were first generated by … into many distinct cell types,
enabling tissue-, disease-, and … Many heart diseases result in defective T-tubule structures …