… solid tumors, pancreatic cancer harbors ample stromal cells … , resulting in persistent and
severe hypoxia within the tumor. … reprogramming, cancer stemness, invasion and metastasis, …

… pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal interaction under
hypoxic … As curcumin can inhibit several important factors secreted by stromal cells, including …

… associated with greater invasive potential in cancer. Through … are expressed in many pancreatic
cancer cell lines and act to … effects of this interaction include increased desmoplasia with …

… aspects of tumor-stromal interactions in the … in hypoxic condition, and, since pancreatic
cancers are hypovascular, PSCs are believed to be the triggering factor for cancer cell invasion …

… role of the stroma and PSCs in PC development, invasion and … tumor development: Hypoxia
induces nuclear factor kappa … to activate pancreatic cancer stem cell markers. These various …

… 6, vascular endothelial growth factor A, and stromal cell-derived … hypoxia-induced pancreatic
cancer cell EMT and invasion. … interaction between pancreatic cancer cells and PSCs under …

… discuss the role of hypoxia on metastasis (invasion and migration), stroma and extracellular
… Moreover, only a small portion of tumor cells have cancer stem cell (CSCs) features with the …

… by both tumor and stromal cells, including immune cells like … production of VEGF and metastatic
progression in hypoxic … -α affects tumor cell growth and invasion in pancreatic tumor both …

… Under normal conditions, PSCs are maintained in a relatively ‘… , and invasion and induce
EMT and cancer stem cell (CSC)-… OPN in the tumor–stroma interactions of pancreatic cancer. …

… the interaction among pancreatic cancer cells, epithelial cells … Pancreatic cancer is a hypoxic
tumor with a distinct hypoxic … and enhances invasiveness and the spread of epithelial cells […