… RGD could target tumor cells, … in glioma cells and the tumor vasculature with a minimal
expression on a normal resting vascular bed [Citation24], thus, our dual-target TGN/RGD delivery …

… delivery of therapeutic agents to cancer cells while minimizing drug toxicity to normal cells
and off-targeting … of highly leaky vasculature and low lymphatic drainage Both are typical in …

… and selectivity, the R8 shell had lower cellular uptake into tumor cells in vivo 46 . For example,
CPPs initially binds to the local vasculature and redistributes to the liver after intravenous …

… -2 and NRP-1 on vasculature endothelial cells or glioma cells; (ii) … dual targeting TAT-AT7-modified
PPTA/pVAXI-En nanocomplex for secretory endostatin gene delivery to treat glioma. …

… in glioma neovasculature compared to peripheral tumors, … α and consequently results in
cancer cells apoptosis. In 2016, the … anti-glioma effect of BTZ in patients with recurrent malignant …

… leaky vasculature and deficient lymphatic drainage in the tumor … the surface of several cancer
cells, including glioma. AS1411 … double targeted nanoparticles showed a superior targeting …

… progression of GBM, 14,15 the BBTB formed by abnormal neovasculature is … dual targeting
ligands could produce a synergistic effect to improve the targeting efficiency to tumour cells …

… of human derived GBM cells, early passaged tumor cells co-opted the brain vasculature,
while at … Spheroids from human glioma patient tumors co-opt the host vasculature, showing an …

… natural process of drug delivery to the glioma TME vasculature (Fig. 4A)… glioma tumor cells
can up take nanoparticles. However, compared to neurons and astrocytes, glioma tumor cells …

… rationale for vasculature-centered treatment … tumor vasculature. We focus on an overview
of the current knowledge of the interplay of cancer cells, endothelial cells, and the immune cell …