Cancer stem cells (CSCs) in cancer progression and therapy
… differentiation of CSCs. When the cells are committed to differentiation, they cannot initiate
tumor growth … of CD51 could be a therapeutic target for restricting progression of prostate …
tumor growth … of CD51 could be a therapeutic target for restricting progression of prostate …
[HTML][HTML] Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
H Zhao, T Ming, S Tang, S Ren, H Yang, M Liu, Q Tao… - Molecular cancer, 2022 - Springer
… promotes cancer stem cell renewal, cell proliferation and differentiation, … target genes provides
a reasonable explanation for how Wnt allows CSC mutations during cancer progression. It …
a reasonable explanation for how Wnt allows CSC mutations during cancer progression. It …
Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player
M Wesseling, JHC de Poel, SCA de Jager - ESC Heart Failure, 2020 - Wiley Online Library
… curative therapy for heart failure is available, co-morbidities influence disease progression …
, we propose that GDF15 may be a valuable therapeutic target in heart failure as it is involved …
, we propose that GDF15 may be a valuable therapeutic target in heart failure as it is involved …
[HTML][HTML] Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
… during the cancer progression and have the potential to be targeted for anticancer therapy.
… signals mediating crosstalk of CAFs with cancer cells and its related targets or trials. Further, …
… signals mediating crosstalk of CAFs with cancer cells and its related targets or trials. Further, …
Therapeutic targeting of the tumor microenvironment
L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
… regulating cancer progression and influencing therapeutic … treatment, strategies to target
the TME have expanded … , which may determine differential therapeutic efficacy, with the latter …
the TME have expanded … , which may determine differential therapeutic efficacy, with the latter …
[HTML][HTML] Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature reviews Drug …, 2022 - nature.com
… from targeting recruitment and differentiation to functional … as therapeutic tools and targets
in cancer therapy, including … , antibiotic treatment can have dual effects on tumour growth …
in cancer therapy, including … , antibiotic treatment can have dual effects on tumour growth …
Tumor microenvironment components: Allies of cancer progression
PIR Franco, AP Rodrigues, LB de Menezes… - … -Research and Practice, 2020 - Elsevier
… targets in the study of tumor biology and oncology therapies [… The stem cell differentiation
mechanism is highly controlled … to tumor progression enable specific therapeutic strategies for …
mechanism is highly controlled … to tumor progression enable specific therapeutic strategies for …
[HTML][HTML] Targeting cancer stem cells for reversing therapy resistance: Mechanism, signaling, and prospective agents
HM Zhou, JG Zhang, X Zhang, Q Li - … transduction and targeted therapy, 2021 - nature.com
… and differentiation potential that contribute to tumor progression and therapy resistance. …
The eventual goal is to investigate why CSCs can escape treatment, be retained, and form a …
The eventual goal is to investigate why CSCs can escape treatment, be retained, and form a …
[HTML][HTML] Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target
… The expression of MDK was correlated with poor tumor cell differentiation (poorly
differentiated tumor cells-weak MDK expression) in ESCC [124]. High serum MDK levels were …
differentiated tumor cells-weak MDK expression) in ESCC [124]. High serum MDK levels were …
[HTML][HTML] Inflammation and tumor progression: signaling pathways and targeted intervention
H Zhao, L Wu, G Yan, Y Chen, M Zhou… - … and targeted therapy, 2021 - nature.com
… modulate inflammation in cancer therapy, with … tumor development and inflammatory
processes. We also highlight potential targets for harnessing inflammation in the treatment of cancer…
processes. We also highlight potential targets for harnessing inflammation in the treatment of cancer…
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- therapeutic target colorectal cancer