Cancer stem cells (CSCs) in cancer progression and therapy

M Najafi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
differentiation of CSCs. When the cells are committed to differentiation, they cannot initiate
tumor growth … of CD51 could be a therapeutic target for restricting progression of prostate …

[HTML][HTML] Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

H Zhao, T Ming, S Tang, S Ren, H Yang, M Liu, Q Tao… - Molecular cancer, 2022 - Springer
… promotes cancer stem cell renewal, cell proliferation and differentiation, … target genes provides
a reasonable explanation for how Wnt allows CSC mutations during cancer progression. It …

Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player

M Wesseling, JHC de Poel, SCA de Jager - ESC Heart Failure, 2020 - Wiley Online Library
… curative therapy for heart failure is available, co-morbidities influence disease progression
, we propose that GDF15 may be a valuable therapeutic target in heart failure as it is involved …

[HTML][HTML] Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
… during the cancer progression and have the potential to be targeted for anticancer therapy.
… signals mediating crosstalk of CAFs with cancer cells and its related targets or trials. Further, …

Therapeutic targeting of the tumor microenvironment

L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
… regulating cancer progression and influencing therapeutictreatment, strategies to target
the TME have expanded … , which may determine differential therapeutic efficacy, with the latter …

[HTML][HTML] Macrophages as tools and targets in cancer therapy

A Mantovani, P Allavena, F Marchesi… - Nature reviews Drug …, 2022 - nature.com
… from targeting recruitment and differentiation to functional … as therapeutic tools and targets
in cancer therapy, including … , antibiotic treatment can have dual effects on tumour growth

Tumor microenvironment components: Allies of cancer progression

PIR Franco, AP Rodrigues, LB de Menezes… - … -Research and Practice, 2020 - Elsevier
targets in the study of tumor biology and oncology therapies [… The stem cell differentiation
mechanism is highly controlled … to tumor progression enable specific therapeutic strategies for …

[HTML][HTML] Targeting cancer stem cells for reversing therapy resistance: Mechanism, signaling, and prospective agents

HM Zhou, JG Zhang, X Zhang, Q Li - … transduction and targeted therapy, 2021 - nature.com
… and differentiation potential that contribute to tumor progression and therapy resistance. …
The eventual goal is to investigate why CSCs can escape treatment, be retained, and form a …

[HTML][HTML] Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target

PS Filippou, GS Karagiannis, A Constantinidou - Oncogene, 2020 - nature.com
… The expression of MDK was correlated with poor tumor cell differentiation (poorly
differentiated tumor cells-weak MDK expression) in ESCC [124]. High serum MDK levels were …

[HTML][HTML] Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - … and targeted therapy, 2021 - nature.com
… modulate inflammation in cancer therapy, with … tumor development and inflammatory
processes. We also highlight potential targets for harnessing inflammation in the treatment of cancer