MET targeting: time for a rematch
JP Koch, DM Aebersold, Y Zimmer, M Medová - Oncogene, 2020 - nature.com
… tyrosine kinase (RTK) for hepatocyte growth factor (HGF) and … its activation and thus promote
invasive growth [35]. Moreover… Hypoxia is one of the mechanisms that can trigger increased …
invasive growth [35]. Moreover… Hypoxia is one of the mechanisms that can trigger increased …
Organ-chip models: opportunities for precision medicine in pancreatic cancer
… , a key event in cancer progression and invasion, responds to … PSCs, macrophages in
interaction with cancer cells can shift … by vascular collapse, hypoxia, and increased stiffness due to …
interaction with cancer cells can shift … by vascular collapse, hypoxia, and increased stiffness due to …
Pancreatic adenocarcinoma invasiveness and the tumor microenvironment: From biology to clinical trials
… increase EMT and invasiveness of pancreatic cancer cell … are secreted by the pancreatic
tumor stromal cells, a small … in hypoxia distribution, which affected both cancer cells and the …
tumor stromal cells, a small … in hypoxia distribution, which affected both cancer cells and the …
The role of C-met activation on the organ specific extravasation in hepatocellular carcinoma cells
G Bağci - acikbilim.yok.gov.tr
… Invasive cancer cells penetrate into the blood vessels via passive … Some of them are listed
as tumor-stromal interactions on a … on the hepatocyte growth factor/c-Met axis in hepatocellular …
as tumor-stromal interactions on a … on the hepatocyte growth factor/c-Met axis in hepatocellular …
Tumor microenvironment features and chemoresistance in pancreatic ductal adenocarcinoma: Insights into targeting physicochemical barriers and metabolism as …
TMA Carvalho, D Di Molfetta, MR Greco, T Koltai… - Cancers, 2021 - mdpi.com
… Therefore, the interaction of multiple ECM proteins to produce … -1α expression increases
pancreatic cancer cell motility and … , in PDAC cells, hypoxia increases the formation of invasive …
pancreatic cancer cell motility and … , in PDAC cells, hypoxia increases the formation of invasive …
Glycolysis-based genes associated with the clinical outcome of pancreatic ductal adenocarcinoma identified by the cancer genome atlas data analysis
G Tian, G Li, P Liu, Z Wang, N Li - DNA and cell biology, 2020 - liebertpub.com
… High MET expression in pancreatic cancer cells and high HGF expression in … migration and
invasion of renal clear cell cancer cells. Hypoxic regulation of SPAG4 could be mediated in a …
invasion of renal clear cell cancer cells. Hypoxic regulation of SPAG4 could be mediated in a …
Targeted therapy for pancreatic cancer: Lessons learned and future opportunities
AG Thomas, N Awasthi - 2021 - scholarworks.iupui.edu
… greater cancer cell proliferation and invasive activity and promotes … The hypoxic environment
in tumor-stromal cells accelerates … the activation of paracrine hepatocyte growth factor/c-Met …
in tumor-stromal cells accelerates … the activation of paracrine hepatocyte growth factor/c-Met …
A receptor-antibody hybrid hampering MET-driven metastatic spread
C Modica, C Basilico, C Chiriaco, N Borrelli… - … & Clinical Cancer …, 2021 - Springer
… and its ligand Hepatocyte Growth Factor (HGF) are at the core of the invasive-metastatic
behavior. … in preventing spreading of pancreatic cancer cells from orthotopic primary tumors. The …
behavior. … in preventing spreading of pancreatic cancer cells from orthotopic primary tumors. The …
Soluble compounds released by hypoxic stroma confer invasive properties to pancreatic ductal adenocarcinoma
D Liu, A Steins, R Klaassen, AP van der Zalm… - Biomedicines, 2020 - mdpi.com
… hypoxia and stroma interact to contribute to invasive growth in … that hypoxia is related with
stroma activation, hypoxia pathway … growth of pancreatic cancer cells and that among these, …
stroma activation, hypoxia pathway … growth of pancreatic cancer cells and that among these, …
[HTML][HTML] The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells
X Zhang, M Zhang, H Sun, X Wang, X Wang… - Journal of Advanced …, 2024 - Elsevier
… Furthermore, SNAIL expression in tumor stromal myofibroblasts … hepatocyte growth factor
(HGF) promotes proliferation, migration, and invasion of GC cells with unamplified MET through …
(HGF) promotes proliferation, migration, and invasion of GC cells with unamplified MET through …