… for SAg-TCR interactions [17,18]. Crucial amino acid residues that contribute to the complex
formation common to all the five SAg-TCR complexes lie in two conserved regions: a strictly …

… with TcR or MHC-II, its role in staphylococcal pathogenesis is … despite having structural and
sequence similarities to common … The staphylococcal enterotoxin gene family contains 24 …

… and stabilize SEB for recognition by the TCR (2). However, the … TCR signalling that upon
stimulation causes an increase in local Ca 2+ levels (62) making CD28 intracytoplasmic motifs …

… However, this distinction has become obsolete since many new toxins were later recognized
as … The shallow cavity between the two domains binds TCR while major histocompatibility …

… Our study is the second to report that staphylococcal enterotoxin predominantly induces
TCR activation through particular Vα segments. Previously, Petersson et al. demonstrated that …

… structure of the complex between a mouse TCR β … structure contains two asymmetrical
copies of SEB-TCR β chain complex, indicating intrinsic flexibility of SEB-TCR β chain recognition (…

… We show that SARS-CoV-2 spike contains sequence and structure motifs highly similar to …
both sequence and structure to the bacterial superantigen staphylococcal enterotoxin B. This …

… crosslinking of T-cell receptors (TCRs) Vβ with MHC class II … the USA are attributed to
Staphylococcal enterotoxins (13). In … the common Gram-positive protein anchoring motif LPXTG (97…

… recognition by the neutrophil receptor [11]. A large family of structurally related toxins,
staphylococcal enterotoxins (… of a superantigen and MHC class II complex by a T-cell receptor …

… to the SARS-CoV2 SAg-like motif, therefore blocking its interaction with the TCR and poten-
… the mechanisms of Ab recognition and neutralization and help screen SARS-CoV-2 Abs for …