Population analysis of Staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia

M Vrieling, SW Tuffs, G Yebra, MY van Smoorenburg… - Mbio, 2020 - Am Soc Microbiol
… SAg with 36% amino acid identity to staphylococcal enterotoxin A (SEA) (15), but … structure
(PBD: 1HXY) and the low-affinity SEA-HLA-DR1 structure (PBD: 1LO5), as well as the TCR

Staphylococcus aureus: setting its sights on the human innate immune system

KD Buchan, SJ Foster, SA Renshaw - Microbiology, 2019 - microbiologyresearch.org
… -recognition receptors (PRRs), which recognize specific pathogen-associated molecular
patterns (… Additionally, this cluster contains staphylococcal enterotoxin A (SEA), which disrupts …

[HTML][HTML] Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1a

E Bryan, JE Teague, S Eligul, WC Arkins… - Journal of Investigative …, 2024 - Elsevier
TCRs that used TRAV34 and TRBV28 variable genes, which is a known motif for recognition
of staphylococcal enterotoxin B, a … We found that these conserved TCRs did not respond to …

Thermal unfolding and aggregation process of recombinant staphylococcal enterotoxin m (rSEM) associated with potential toxin responsible for staphylococcal food …

J Liu, W Tian, J Tang, J Chen, Y Zhao, J Yu - 2021 - cabidigitallibrary.org
… In this study, the heat-induced conformational changes of recombinant staphylococcal
enterotoxinTwo common structural motifs for TCR recognition by staphylococcal enterotoxins[J]. …

[PDF][PDF] In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate

M Nazari, F Badmasti - Vaccine Research, 2020 - vacres.pasteur.ac.ir
… cells and T cell receptors (TCRs) with specific Vβ elements [4]. … are antigenic determinants
that are recognized by the immune … modified recombinant staphylococcal enterotoxin B protein …

Staphylococcal enterotoxins as good candidates for cancer immunotherapy: a systematic review

A Shivaee, M Sedighi, AAI Fooladi - Annali Di Igiene Medicina …, 2020 - eprints.bmsu.ac.ir
… the variable (3) region of the TCR β chain (TCR V β, in the outer … Secondly, there was a
considerable heterogeneity in designs, … Identification of the antigenic epitopes in staphylococcal …

[HTML][HTML] Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

RA Porritt, L Paschold, MN Rivas, MH Cheng… - bioRxiv, 2020 - ncbi.nlm.nih.gov
Staphylococcal enterotoxin B (SEB). SAgs are highly potent T cell activators able to engage
both T cell receptors (TCRs… Vβ11–2 played a significant role in binding to these two motifs on …

Oral exposure to Staphylococcus aureus enterotoxin B could promote the Ovalbumin-induced food allergy by enhancing the activation of DCs and T cells

J Yuan, P Tong, X Meng, Y Wu, X Li, J Gao… - Frontiers in …, 2023 - frontiersin.org
… cavity, thereby affecting the recognition and uptake of allergens and … To investigate biological
themes among our list of … T cells by cross-linking MHC and TCR with the presence of APCs, …

Exploring staphylococcal superantigens to design a potential multi-epitope vaccine against Staphylococcus aureus: an in-silico reverse vaccinology approach

S Rahman, K Sarkar, AK Das - Journal of Biomolecular Structure …, 2023 - Taylor & Francis
… peptides derived from antigens and recognized by the T-cell receptor (TCR) when bound
to … This study explores staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB) …

Staphylococcus aureus Exotoxins and Their Detection in the Dairy Industry and Mastitis

A G. Abril, T G. Villa, J Barros-Velázquez, B Cañas… - Toxins, 2020 - mdpi.com
… The association of SAgs, MHC class II, and the TCR β-chain … , which means that staphylococcal
enterotoxin C is involved … a special focus on enterotoxin identification in foodstuffs [8]. …