Analysis of non-volatile metabolites and quantitation of the anti-arthritic alkaloid sinomenine from blood fruit (Haematocarpus validus (Miers) Bakh.f. ex Forman)

BK Alex, U Anand, EP Koshy, A Dey… - … Archives of Pharmacology, 2023 - Springer
… (S)-reticuline gives rise to a number of bases including sinomenine-a morphinanalkaloid
sinomenine other than Sinomenium acutum; Sinomenine is reported to exhibit COX 1, COX 2 (…

Mechanism underlying antitumor effects of sinomenine

L Gao, B Zhong, Y Wang - Chinese journal of integrative medicine, 2019 - Springer
… sinomenine (7,8-didehydro-4hydroxy-3,7-dimethoxy-17-methyl morphinane-6-… alkaloid
compound extracted from a Chinese medicinal plant Sinomenium acutum Sinomenium acutum. It …

Integrated Strategy of Mass Spectrometry Imaging and Lc/Ms-Based Gnps for Spatial Characterization of Alkaloids from Menispermi Rhizoma and Study on Potential …

K Li, S Xiao, L Zhu, L Shu, Y Zou, J Wang… - … of Alkaloids from … - papers.ssrn.com
Morphinane alkaloids usually tend to lose either C2H5N or C3H7N, then form a stable ternary
ring by loss of CO, CH4O, CH2O or lose of HCl to form a double … , Sinomenium acutum, …

Isolation, biosynthesis, and chemical syntheses of the hasubanan and acutumine alkaloids: A historical perspective

DC Grünenfelder, SE Reisman, R Navarro - Tetrahedron, 2023 - Elsevier
… motif observed to arise from the degradation of morphine alkaloids (Scheme 1). In addition,
… In 1929, Goto and Sudzuki reported the isolation of acutumine from Sinomenium acutum, a …

Anti-breast cancer sinomenine derivatives via mechanisms of apoptosis induction and metastasis reduction

X Gao, B Sun, Y Hou, L Liu, J Sun, F Xu… - Journal of Enzyme …, 2022 - Taylor & Francis
… Sinomenine, a morphinane-type isoquinoline-derived alkaloid, was first isolated from
stems and roots of Sinomenium diversifolius (Miq.) in 1920. Later discovery by researchers …

Discovery of sinomenine/8-Bis (benzylthio) octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway

X Gao, H Li, S Wang, X Long, X Guo, H Hua… - Bioorganic & Medicinal …, 2024 - Elsevier
… from the dried canes of Sinomenium acutum (Thunb.) Rehd. et Wils. … of alkaloids is as diverse
as their biological effects. By aforementioned chemical and biological diversity of alkaloids, …

Synthesis of alkaloid sinomenine derivatives containing a pyrimidine substituent in ring A

AO Finke, VG Kartsev, EE Shults - Chemistry of Heterocyclic Compounds, 2021 - Springer
… The alkaloid sinomenine, an enantiomer of the morphinane alkaloid codeine, characterized
… first isolated in 1920 from the East Asian plant Sinomenium acutum (Thunb.) Rehd. et Wils. …

Alkaloids: Their relevance in cancer treatment

C Varela, F Silva, G Costa, C Cabral - New Insights Into Glioblastoma, 2023 - Elsevier
… Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum [45]. Lycorine …
Despite there being already some alkaloids used in clinic, such as morphine and ephedrine […

Development of Macromolecular Prodrug of Sinomenine for the Treatment of Rheumatoid Arthritis

R Mukundan - 2021 - digitalcommons.unmc.edu
… Sinomenine is a natural alkaloid obtained from the Chinese medicinal plant Sinomenium
acutum … The structure of sinomenine is similar to the other natural alkaloids like morphine. All of …

Isoquinoline alkaloids and chemotaxonomy

AR dos Santos, NP Vaz - Biodiversity and Chemotaxonomy, 2019 - Springer
… route of the morphinan alkaloids (Liscombe and Facchini 2008; Dewick 2002). … of alkaloids
with the most diverse skeletons. For example, the chemical study of the Sinomenium acutum