… -1 monomers, which promotes its self-cleavage and activation. Consequently, active …
NLRP3-mediated caspase-1 activation through fatty acid synthase (FASN)-mediated lipid synthesis…

… hypothesis that UCP2 might regulate NLRP3 inflammasome activation and participate in the
… indicated that caffeine citrate could promote UCP2 expression, and inhibit the activation of …

… that TXNIP/NLRP3 signaling is critical for the pathogenesis of sepsis-… activities of fatty acid
synthesis and fatty acid degradation … that glycolysis may promote the NLRP3 inflammasome. …

… PC promotes the full activation of the NLRP3 inflammasome via … of fatty acid synthase (FASN),
a key enzyme of fatty acid … and LPS-induced septic shock in NLRP3 knockout mice [166]. …

… and serious complication of sepsis, and sepsis is the leading … inflammatory factors and
promoted NF-κB activation in LPS-… of organ dysfunction during sepsis. UCP2 localizes to …

… Fatty acid synthesis and fatty acid oxidation regulate the priming and activation of the NLRP3
inflammasome… ; yet, perturbations at marked points can inhibit or promote NLRP3 activation…

… of sepsis [30], but it also acts as a “metabolic switch” connecting glucose oxidation and
mitochondrial metabolism, promoting the oxidation of glutamine and fatty acids instead of glucose…

… , which can generate NADPH for fatty acid synthesis and ribose-5-phosphate for nucleoside
… by promoting NLRP3 inflammasome activation but also promotes macrophage activation …

… and inflammation promotes mitochondrial biogenesis and fatty acid … acid synthase (Fasn)-dependent
lipid synthesis (102). … have important functions beyond inflammation and infection. …

… Our study suggests a non-canonical role of mitochondrial PDHK in promoting mitochondrial
stress and supporting NLRP3 inflammasome activation during acute inflammation. …