Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
… transcript degradation and mRNA decay in host-temperature … demonstrate that adaptation
to host temperature and immune … its transcriptome, further impairing its stress responsiveness. …
to host temperature and immune … its transcriptome, further impairing its stress responsiveness. …
Current insight into the role of mRNA decay pathways in fungal pathogenesis
Z Firdous, S Kalra, R Chattopadhyay, VK Bari - Microbiological Research, 2024 - Elsevier
… several strategies to adapt to the host environment resulting in … , and body temperature induce
the targeted degradation of … modifications regulate mRNA stability, which affects a range of …
the targeted degradation of … modifications regulate mRNA stability, which affects a range of …
Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction
CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
… adaptations we observed in C. neoformans, we compared the responses to both temperature
… translational response to temperature is driven mainly by Ccr4-dependent mRNA decay, …
… translational response to temperature is driven mainly by Ccr4-dependent mRNA decay, …
When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule
MP Duviau, F Chen, A Emile… - Nucleic Acids …, 2023 - academic.oup.com
… To characterize the interplay between mRNA degradation … stop codon, due to the uncoupling
of transcription and translation. … following temperature program: 2 min at 50C, 30 min at 70C …
of transcription and translation. … following temperature program: 2 min at 50C, 30 min at 70C …
Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans
ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
… participate in adaptation to growth at 37C and that, while Ccr4-mediated mRNA decay is not
a … either directly or indirectly modulates Hog1 activation during host temperature adaptation. …
a … either directly or indirectly modulates Hog1 activation during host temperature adaptation. …
Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans
J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
… and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to …
orange stains incubated with cultures at room temperature for 30 min. Yeast were then fixed …
orange stains incubated with cultures at room temperature for 30 min. Yeast were then fixed …
The essential role of mRNA degradation in understanding and engineering E. coli metabolism
C Roux, TA Etienne, E Hajnsdorf, D Ropers… - Biotechnology …, 2022 - Elsevier
… degradation affects mRNA concentrations and should … and decoupling transcription and
translation) accelerates mRNA … mRNA degradation regulation and metabolic adaptations to …
translation) accelerates mRNA … mRNA degradation regulation and metabolic adaptations to …
The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
… that cool adaptation suppresses glycolysis, along with impaired … uncoupled mitochondrial
respiration in cool-adapted … thermogenesis, since Ucp1 mRNA expression is unchanged (NCBI …
respiration in cool-adapted … thermogenesis, since Ucp1 mRNA expression is unchanged (NCBI …
UCP1-independent thermogenesis
A Roesler, L Kazak - Biochemical Journal, 2020 - portlandpress.com
… UCP1 uncouples electron transport from ATP synthesis by … ATP synthesis [118], and BAT
mitochondria from cold-adapted … with impaired whole body acylglycerol synthesis argues …
mitochondria from cold-adapted … with impaired whole body acylglycerol synthesis argues …
[PDF][PDF] Numerous post-translational modifications of RNA polymerase II subunit Rpb4/7 link transcription to post-transcriptional mechanisms
… affects mRNA synthesis, whereas the other affects mRNA … thal temperature (33 C) and
determined the steady-state mRNA … distinct functions that can be uncoupled by specific mutations. …
determined the steady-state mRNA … distinct functions that can be uncoupled by specific mutations. …