… mRNA deadenylase Ccr4, are unable to respond and adapt to physiologically relevant stresses
such as host temperature and … by cycloheximide protects mRNAs from degradation [10]. …

… In this study, we demonstrate for this critical adaptation, the Cu-… of the SOD1 and SOD2
mRNAs through specific binding to Cu … Further, decoupling Cuf1 regulation of Sod2 localization …

… shifted to the nonpermissive temperature, the lcb1-100 strain (impaired in sphingolipid …
translation and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to …

… [22], major metabolic adaptation has to occur. Interestingly, … dispersed in ultra-low temperature
agarose at 4 C for 30 min. … Here, we sought to investigate if low glucose by itself affects …

… proteins facilitate adaptation to the host environment mitigating … Mutants lacking DNJ4 were
also impaired in the in vitro … are able to grow and survive at elevated temperatures and can …

… residues on growth at different temperatures. Both methyl-deficient … associated with impaired
induction of LAC1 expression … study were derived from Cryptococcus neoformans var. grubii …

… affects mRNA synthesis, whereas the other affects mRNA … thal temperature (33 C) and
determined the steady-state mRNA … distinct functions that can be uncoupled by specific mutations. …

… the human fungal pathogen Cryptococcus neoformans. mBio 2019, … Uncoupling of mRNA
synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans…

… host, two phenotypes largely determine a successful infection: growth at host physiological
temperature (37C) … a transcript degradation site, SGs are believed to regulate mRNA storage, …

… , is generally associated with impaired fitness and developmental … , extreme temperatures
and those mimicking wild or host … , while increased ERG11 mRNA expression was observed in …