… mechanisms from immune recognition and destruction, such as … Those bispecific ta-scFv
antibodies recognizing a tumor cell … be implemented to the generation of universal STAb-T cells. …

… in the vicinity of the antibody-targeted tumor cell. We generated … be transduced into murine
cytotoxic T cells with comparable … -target effects or organ damage was being caused by SAR T …

… attack and lysis of target tumor cells. Although various bsAb … bsAb, namely, a universal effector
module and a target module, … , alleviating the collateral damage of adjacent healthy tissues…

… that CD28-deficient cytotoxic T-cells were still capable of … D) The copy number of the
targeted antigen on the tumor cell … However, this is not an universal feature as some Ab formats …

… damage, preferentially kills regulatory T cells (Treg), induces an acute secretory activating
phenotype in tumor cells … Tnfrsf17 is universally expressed in all normal and malignant PCs at …

… Bispecific antibodies tether tumor cells to T lymphocytes (… also lack a universally expressed
tumor-specific antigen which … and tumor cells (such as granzyme B-mediated damage to the …

… and antibody-based reagents could efficiently kill tumor cells in vitro, … T-cells can be directed
against tumor cells either by using bispecific antibodies (30) or by engineered CAR T-cells…

… toxicity and damage to normal brain 1 . In 2017, CAR-… infiltrated brain tumors, but viable
tumor universally remained and … T cells maintained the capacity to efficiently lyse tumor cells …

… Bispecific antibodies targeting CD3 on T cells and a tumor antigen on cancer cells have …
We hypothesize that lack of damage to ovary and heart is due to insufficient LYPD1 …

… In an effort to design this universal CAR T cell, we examined … activation and the subsequent
destruction of the cancer cell. … a CAR T cell and its targeted tumor cell should promote a …