… mice lacking at least one MMP gene have been engineered … Double knockout mice
lacking MMP-9 and MMP-13 exhibit … of mice with a double knockout for MMP-14 and MMP-2 …

… mice line lacking both MMP2 and MMP9, which can help decipher the individual/mutual role
of both gelatinases and fully characterized their skeletal … lines unraveled a unique role of …

… genetically engineered mouse models (GEMMs) lacking all four TIMP genes. Complete TIMP
deficiency produces severe skeletal … Using compound GEMMs, we rescue the bone defects …

… immense potential for unraveling the complex networks involved in skeletal development and
… Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of …

… In a follow-up study, an effort was put to unravel the role of such MMP11-driven metabolic …
Generation of genetic-engineered mice targeting MMP14 brought novel insight into the role …

… role of MMP‐10 through bone regeneration in C57BL/6 mice. … marrow, indicating that MMP‐10
functions are required only in … Our data provide evidence of the in vivo function of MMP‐10 …

… are inhibited by the four tissue inhibitors of metalloproteinase called TIMPs. We … for skeletal
homeostasis. We bred individual Timp knockout mice to generate unique mouse models, the …

… system and many matrix metalloproteinases, that might be … Type mice, we prepared (n =
5) female mouse femurs using … Unraveling the human bone microenvironment beyond the …

… We investigate the role of Matrix Metalloproteinase 3 (MMP3) on bone in mice, by using Mmp3
… of genetically engineered mouse models, although individual TIMPs deletion has induced …

… Genetically modified mice have provided novel insights into the mechanisms of activation …
have provided phenocopies of acquired human disease such as rickets and osteomalacia and …