[HTML][HTML] Disentangling ERBB signaling in breast cancer subtypes—A model-based analysis

S Kemmer, M Berdiel-Acer, E Reinz, J Sonntag… - Cancers, 2022 - mdpi.com
… the ERBB signaling network … the ERBB signaling network as displayed in Figure 2. Reaction
kinetics were modeled by the law of mass-action according to chemical reaction network

[HTML][HTML] The ErbB signaling network and its potential role in endometrial cancer

G Androutsopoulos, I Styliara, E Zarogianni, N Lazurko… - Epigenomes, 2023 - mdpi.com
… Some of these pathways are part of the EGF system signaling network, which becomes …
Our aim is to provide an update on current knowledge of the signaling network of ErbB

[PDF][PDF] Disentangling ERBB Signaling in Breast Cancer Subtypes—A Model-Based Analysis. Cancers 2022, 14, 2379

S Kemmer, M Berdiel-Acer, E Reinz, J Sonntag… - 2022 - academia.edu
… the ERBB signaling network … the ERBB signaling network as displayed in Figure 2. Reaction
kinetics were modeled by the law of mass-action according to chemical reaction network

[HTML][HTML] Homo-and heteroassociations drive activation of ErbB3

T Váradi, M Schneider, E Sevcsik, D Kiesenhofer… - Biophysical journal, 2019 - cell.com
… Dimerization or the formation of higher-order oligomers is required for the activation of ErbB
receptor … Untangling the ErbB signalling network. … Untangling the ErbB signalling network. …

Growth factor–dependent ErbB vesicular dynamics couple receptor signaling to spatially and functionally distinct Erk pools

Y Brüggemann, LS Karajannis, A Stanoev… - … Signaling, 2021 - science.org
… The ErbB signaling network coordinates fundamental, often opposing cellular responses,
such as proliferation and differentiation, and thus functions as important context-dependent …

Antitumour immunity regulated by aberrant ERBB family signalling

S Kumagai, S Koyama, H Nishikawa - Nature Reviews Cancer, 2021 - nature.com
… Oncogenic alterations of genes encoding members of the ERBB family, leading to aberrant
ERBB signalling and driving tumour growth, have been reported in various types of cancer …

[HTML][HTML] Origin of diverse phosphorylation patterns in the ERBB system

T Okada, H Miyagi, Y Sako, M Hiroshima… - Biophysical Journal, 2022 - cell.com
Untangling the ErbB signalling network. … phosphorylation levels influence the downstream
signaling. To understand the role of the ERBB network in signaling pathways totally, we need …

Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice

K Hedegger, H Algül, M Lesina, A Blutke… - Molecular …, 2020 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) will soon belong to the top three cancer killers.
The only approved specific PDAC therapy targets the epidermal growth factor receptor (EGFR…

[HTML][HTML] Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs

L Pinet, N Assrir, C van Heijenoort - Biomolecules, 2021 - mdpi.com
… IDRs were also shown to be important for kinase regulation in signaling networks [95]. Even
though mutations in the CT of ErbBs are much less commonly linked to disease compared to …

[HTML][HTML] Insights on the functional interaction between group 1 metabotropic glutamate receptors (mGluRI) and ErbB receptors

A Ledonne, NB Mercuri - International journal of molecular sciences, 2020 - mdpi.com
… Available evidence suggests that mGluRI activity is tightly dependent on ErbB signaling,
and that ErbB’s modulation profoundly influences mGluRI-dependent effects on …