… lysins, understanding phage hijacking mechanisms can uncover numerous novel targets
either for existing antibacterial … using omics studies in antimicrobial development. The authors …

… the development of novel alternative antimicrobial … targeted bacteria due to a readily
accessible peptidoglycan [13,14]. In contrast, the antimicrobial effects of exogenously added lysins …

… The aim of this study is to review the possibilities for the … by the presence of arginine, lysine
and/or histidine residues, and the … The development of phage peptide libraries represents a …

… that have been developed to enable lysins to target G-ve bacteria in the past decade. While
… As the development of new antibiotics is slow comparing with the rapid emergence of MDR …

… However, the lysins currently under development are still … encoding lysin was identified in
the SAP-26 phage genome … has an extended antibacterial activity and can target both Gram…

… Bacteriophage endolysins (lysins) can be used as novel … monitoring targets in clinical
microbiology because these antibiotics … efforts in drug development for new antimicrobial agents. …

… development of derivatives of known antibiotics rather than discovery of antimicrobials with
fundamentally new … The protein origin of lysins should induce immune response in mammals …

… and the lack of new antibiotics calls for the development of new antibacterial drugs or …
development of antibiotic resistance. Since most of the phage lysins are used externally and target …

… new virions from the cell [13]. The catalytic domains of … low probability of the development of
bacterial resistance to lysins. A … of this family are lytic, they have potential use as antibacterial …

… development of pneumococcal resistance to commonly used … human saliva against the target
strains Streptococcus infantis … The use of antibiotics to remove biofilms is seen as critical [36…