Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use

A Nogales, ML DeDiego… - Frontiers in cellular and …, 2022 - frontiersin.org
… protein to prevent swine influenzavaccines for the prevention of SIV infections in pigs, in
this review we focus on the implementation of NS1 truncated or deficient viruses for their use as …

Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge

J Lee, Y Li, Y Li, AG Cino-Ozuna, M Duff, Y Lang, J Ma… - Vaccine, 2021 - Elsevier
… However, there are safety concerns of using LAIVs that … new MLV vaccine candidates for
swine influenza using an … efficacious live virus vaccines to prevent SIV infections in pigs and …

[HTML][HTML] Efficacy of the NS1-truncated live attenuated influenza virus vaccine for swine against infection with viruses of major north American and European H3N2 …

E Vandoorn, A Parys, S Chepkwony, K Chiers… - Vaccine, 2022 - Elsevier
NS1-truncated H3 swine influenza vaccine provides partial heterologous protection. … dpc,
VN titers of 4–8 against TX98 were found for only 4 vaccinated pigs: 1 pig in the LAIV/TX98 and …

Pathobiology of an NS1-truncated H3N2 swine influenza virus strain in pigs

E Vandoorn, W Stadejek, A Parys… - Journal of …, 2022 - Am Soc Microbiol
… Virus strains in the live attenuated influenza vaccine (LAIV) for swine in the United States
that was on the market until 2020 encode a truncated nonstructural protein 1 of 126 amino …

Novel approaches for the development of live attenuated influenza vaccines

P Blanco-Lobo, A Nogales, L Rodríguez… - Viruses, 2019 - mdpi.com
… , mainly against the influenza A virus (IAV) component of the vaccine. Although the … from
A/Swine/Saskatchewan/18789/02 H1N1 SIV [211]. This virus was highly attenuated in pigs

Detection of live attenuated influenza vaccine virus and evidence of reassortment in the US swine population

A Sharma, MA Zeller, G Li, KM Harmon… - Journal of …, 2020 - journals.sagepub.com
… and potential vaccine virus reassortment with endemic influenza A virus (IAV) in swine. …
by PCR in LAIV vaccinated pigs is ambiguous given that the vaccine contains 2 subtypes, …

Influenza A virus in swine: epidemiology, challenges and vaccination strategies

JC Mancera Gracia, DS Pearce, A Masic… - Frontiers in Veterinary …, 2020 - frontiersin.org
swine influenza viruses may have a broader host range when compared to human or avian
viruses and that pigs … , one with a NS1-truncated cluster I H3N2 strain and the other with a ts …

Generation of DelNS1 influenza viruses: a strategy for optimizing live attenuated influenza vaccines

P Wang, M Zheng, SY Lau, P Chen, BWY Mok, S Liu… - MBio, 2019 - Am Soc Microbiol
… An NS1-truncated vaccine induces strong immune responses and appears to exert better …
of H3N2 or H1N1 viruses also cross protect against swine influenza viruses in pigs (25…

Development of in ovo-compatible NS1-truncated live attenuated influenza vaccines by modulation of hemagglutinin cleavage and polymerase acidic X frameshifting …

A Ghorbani, JM Ngunjiri, MEC Abundo… - Vaccine, 2023 - Elsevier
Live virus isolation was attempted by passaging the swab … , we designed an NS1-truncated
LAIV for in ovo vaccination of … concerns related to the use of live vaccines on farms. In ovo …

Immunogenicity and protective efficacy of A recombinant pichinde viral-vectored vaccine expressing influenza virus hemagglutinin antigen in pigs

S Kumari, J Chaudhari, Q Huang, P Gauger… - Vaccines, 2022 - mdpi.com
… lavage fluid of pigs in T01 … vaccine elicited protective immunity against IAV-S challenge.
This study shows that rPICV is a promising viral vector for the development of vaccines against