Checkpoints and beyond–immunotherapy in colorectal cancer

T Gutting, E Burgermeister, N Härtel… - Seminars in Cancer …, 2019 - Elsevier
… alone or in combination with dendritic cells (DCs). Other … A clinical trial which combined a
mutant RAS peptide vaccine with … therapy consisting of tumor lysate-pulsed DCs and CIKs after …

[HTML][HTML] Colorectal cancer vaccines: The current scenario and future prospects

W Jia, T Zhang, H Huang, H Feng, S Wang… - Frontiers in …, 2022 - frontiersin.org
Dendritic cell (DC) vaccines utilize DCs loaded with tumor antigens ex vivo or transfected to
… clinical trials of melanoma and prostate cancer (52), are commonly studied in CRC as well. …

[HTML][HTML] Effect of autologous dendritic cell cytokine-induced killer on refractory metastatic colorectal cancer: a matched case–control comparative study

SC Chang, TW Ke, WTL Chen, WC Shyu… - Frontiers in …, 2024 - frontiersin.org
… , such as cytokine-induced killer (CIK), dendritic cell vaccine (DCV), or dendritic cell-cytokine…
immunotherapy for refractory lymphoblastic leukemia (4) and metastatic melanoma (5). …

Analysis of the clinical efficacy of dendritic cell–cytokine induced killer cell-based adoptive immunotherapy for colorectal cancer

H Xu, W Qin, H Feng, D Song, X Yang… - Immunological …, 2021 - Taylor & Francis
… This study evaluated cellular immune function and efficacy before and after DC-CIK … in
patients with colorectal cancer and further confirmed the efficacy and safety of adoptive cellular

[HTML][HTML] Moving on from sipuleucel-T: new dendritic cell vaccine strategies for prostate cancer

SIM Sutherland, X Ju, LG Horvath, GJ Clark - Frontiers in immunology, 2021 - frontiersin.org
… In melanoma patients immature and mature MoDC preps were compared … metastatic
colorectal cancer, a small, randomized phase I DC vaccine trial randomized tumor lysate pulsed

Autologous dendritic cell-cytokine induced killer cell immunotherapy combined with S-1 plus cisplatin in patients with advanced gastric cancer: a prospective study

G Qiao, X Wang, L Zhou, X Zhou, Y Song, S Wang… - Clinical Cancer …, 2019 - AACR
… the staging of patients with AGC (28). In this study we have continuously validated the
patient allocation design termed as the prospective patient's preference-based study (PPPS) in …

[HTML][HTML] Redefining the battle against colorectal cancer: a comprehensive review of emerging immunotherapies and their clinical efficacy

S Shebbo, N Binothman, M Darwaish, HA Niaz… - Frontiers in …, 2024 - frontiersin.org
… and dendritic cell (DC)-based vaccines. Table 1 summarizes … the function of autologous
tumor lysate-pulsed DCs in boosting … NSCLC, melanoma, GC, renal cell carcinoma, head and …

Dysregulated NF-κB–dependent ICOSL expression in human dendritic cell vaccines impairs T-cell responses in patients with melanoma

DM Maurer, J Adamik, PM Santos, J Shi… - Cancer immunology …, 2020 - AACR
dendritic cell (DC) vaccines used to treat 35 patients with melanoma. We showed that
checkpoint molecules induced by ex vivo maturation correlated with in vivo DC vaccine activity. …

[HTML][HTML] Immunotherapy: recent advances and its future as a neoadjuvant, adjuvant, and primary treatment in colorectal cancer

I Yu, A Dakwar, K Takabe - Cells, 2023 - mdpi.com
… , it was demonstrated that one in every four to five patients with melanoma, renal cell carcinoma
Dendritic cell (DC) vaccines are most frequently created by pulsing DCs with autologous …

Efficacious Dendritic Cell Based Immunotherapy for Advanced Solid Tumors: Three Case Studies

IN Carrera, FS Rampersad… - Medical & Clinical …, 2021 - medclinrese.org
… ) carried out preclinical studies on murine colorectal tumor by combining … Vaccination of
pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells