Mechanisms ensuring endothelial junction integrity beyond VE-cadherin

CN Duong, D Vestweber - Frontiers in Physiology, 2020 - frontiersin.org
… This also highlights a central difference between endothelial junctions in vitro and in vivo. In
… Furthermore, it was found recently that local microvascular leakage promotes movement of …

VE-cadherin endocytosis controls vascular integrity and patterning during development

CM Grimsley-Myers, RH Isaacson, CM Cadwell… - Journal of Cell …, 2020 - rupress.org
… defects in VE-cad DEE/DEE mutants, we performed ex vivo aortic … cadherin-independent
roles for p120 in vascular endothelial … expression levels are the critical determinant controlling …

Interference with ESAM (endothelial cell-selective adhesion molecule) plus vascular endothelial-cadherin causes immediate lethality and lung-specific blood …

CN Duong, AF Nottebaum, S Butz… - … , and Vascular …, 2020 - Am Heart Assoc
… We conclude that ESAM is essential for vascular integrity in … ) with mouse lung microvascular
endothelial cells (MLMVEC) … vivo results (Figure 1C), the mAb BV13 against VE-cadherin

[HTML][HTML] Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Y Jin, Y Ding, M Richards, M Kaakinen… - Nature Cardiovascular …, 2022 - nature.com
Vascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential component
of the vascular … was seen in vitro; exposure of human umbilical vein endothelial cells (…

Talin-dependent integrin activation regulates VE-cadherin localization and endothelial cell barrier function

FE Pulous, CM Grimsley-Myers, S Kansal… - Circulation …, 2019 - Am Heart Assoc
… junction protein VE (vascular endothelial)-cadherin. Previous … both in vivo and in vitro data
that support a role for talin in VE-… required for AJ stability and integrity of the endothelium. …

Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia

N Bréchot, A Rutault, I Marangon, S Germain - Seminars in Cell & …, 2023 - Elsevier
… -cadherin antibody was responsible for a major vascular … surface of vascular endothelial
cells and plays a pivotal role for … vivo, microvascular human ECs (HMEC) and human umbilical …

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury

WK Yu, JB McNeil, NE Wickersham, CM Shaver… - Critical Care, 2019 - Springer
… Injury and dysfunction of the microvascular endothelium, the pathophysiologic hallmarks of
… in this study are reflective of decreased adherens junction integrity in vivo. In our study, the …

PI3KC2β inactivation stabilizes VEcadherin junctions and preserves vascular integrity

T Anquetil, R Solinhac, A Jaffre, G Chicanne… - EMBO …, 2021 - embopress.org
vascular endothelial (VE)‐cadherin‐mediated homotypic cell–cell adhesion, is a key determinant
of vascular … To gain insight into the role of PI3KC2β in endothelium integrity in vivo, we …

Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage

H Takase, SHY Chou, G Hamanaka, R Ohtomo… - Neurology, 2020 - AAN Enterprises
… , we performed in vitro studies to determine the effect of sVE-cadherin on microglia, the major
… that during brain inflammation, sVE-cadherin is released from injured brain microvascular

Losartan protects against myocardial ischemia and reperfusion injury via vascular integrity preservation

Y Li, Y Yao, J Li, Q Chen, L Zhang… - The FASEB …, 2019 - Wiley Online Library
… of Src and vascular endothelial cadherin (VE-cadherin), which … permeability and inflammation
in vitro. HUVECs were seeded in … Microvascular dysfunction promotes edema and vascular