… whether CFS genes were or not genuine cancer gene targets … WWOX behaves as a
low-penetrance tumor suppressor with … tumor progression rather than initiation in specific tumor …

… 8 contains the common fragile site FRA16D which would be the … light on the tumor suppressor
activity of WWOX. Different … HR, the mechanism by which WWOX acts on this DNA repair …

… basis for WWOX acting as a suppressor of tumor growth by … non-classical tumour suppressor
functions of WWOX and the … Furthermore, WWOX acts to moderate the mitochondrial …

… (WWOX) at FRA16D and Parkinson Disease-2 (PARK2) at FRA6E [3,4]. The second most
fragile gene, WWOX, … of chromosome breakage at FRA16D increases when patients have a …

… tumor suppressor WWOX spans FRA16D, a common fragile site that is commonly altered in
breast cancer… this mutation impairs the tumor suppressor function of WWOX. Other miRNAs, …

… Overall, our work reveals that the gene product of FRA16D, which has been proposed to
be … We argue that WWOX acts as an inhibitor of metastasis through changes in multicellular …

… as a tumor suppressor gene, WWOX genetic alternations … These findings strongly suggest
that WWOX protein acts as … Considering that WWOX is located in FRA16D (a genomic …

… In addition to identifying the FOR (WWOX) gene, our lab … deletion at the FRA16D fragile
site in cancer cells. First, the … tumour suppressor’ behaviour of WWOX. Fragile sites, and the …

… (FRA16D), is commonly altered in pancreatic cancer. However, the direct contribution of
WWOX loss to pancreatic cancer development and … that WWOX acts as a barrier to halt tumor …

… WWOX (WW-domain containing oxidoreductase) gene harbours the second most common
fragile site, FRA16D, … Our findings suggest that WWOX acts as a tumor suppressor in cervical …