[HTML][HTML] Head and neck squamous cell carcinoma

DE Johnson, B Burtness, CR Leemans… - Nature reviews Disease …, 2020 - nature.com
… that HPV-positive HNSCC could be prevented by successful vaccination campaigns worldwide…
HNSCC of the oral cavity is generally treated with surgical resection, followed by adjuvant …

The complex molecular genetics of familial hypercholesterolaemia

AJ Berberich, RA Hegele - Nature Reviews Cardiology, 2019 - nature.com
… transfer protein, or PSCK9; and gene therapy) can trace their development to the need to …
FH to prevent the early onset of cardiovascular disease (CVD) 2 . However, despite being an

Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

WK Chung, K Erion, JC Florez, AT Hattersley… - Diabetes …, 2020 - Am Diabetes Assoc
… Identifying predictive markers (especially genetic markers) of serious adverse events in
patients treated with these drugs presents an additional area urgently in need of greater attention…

[HTML][HTML] Return of individual genomic research results: are laws and policies keeping step?

A Thorogood, G Dalpé, BM Knoppers - … Journal of Human Genetics, 2019 - nature.com
… economic or psychological harm, such as genetic discrimination. Numerous national laws
[24;… ’s genetic information law authorises the disclosure of individual results that may prevent “…

You are what you eat: diet, health and the gut microbiota

N Zmora, J Suez, E Elinav - Nature reviews Gastroenterology & …, 2019 - nature.com
… During food shortage, bacteria can switch between energy sources by employing sensing
and regulatory mechanisms controlling gene expression. Taxa that can readily adjust to …

[HTML][HTML] Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

A Promonet, I Padioleau, Y Liu, L Sanz… - Nature …, 2020 - nature.com
… arrest at TTS is an active process that prevents collisions between RNA and DNA polymerases,
as previously reported in budding yeast 58,59 . Transient fork pausing could help cells …

[HTML][HTML] High-fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites

J Yang, H Wei, Y Zhou, CH Szeto, C Li, Y Lin… - Gastroenterology, 2022 - Elsevier
… Moreover, we treated patient-derived CRC organoids with NDGA and nervonic acid respectively
and found that both NDGA and nervonic acid could significantly inhibit CRC organoids …

[HTML][HTML] A narrative review of stigma related to infectious disease outbreaks: what can be learned in the face of the Covid-19 pandemic?

F Saeed, R Mihan, SZ Mousavi, RLEP Reniers… - Frontiers in …, 2020 - frontiersin.org
… Reports of people with Asian phenotype who have been victims of racist attacks on several
occasions is proof of stigma and discrimination that could have been avoided (32, 33). …

An evaluation (and vindication?) of Lewis Terman: What the father of gifted education can teach the 21st century

RT Warne - Gifted Child Quarterly, 2019 - journals.sagepub.com
… This article explores the most common criticisms of Terman’s legacy: an overemphasis
on IQ, support for the meritocracy, and emphasizing genetic explanations for the origin of …

Rational combinations of targeted cancer therapies: background, advances and challenges

H Jin, L Wang, R Bernards - Nature Reviews Drug Discovery, 2023 - nature.com
… Over the past two decades, elucidation of the genetic defects that underlie cancer has resulted
in a plethora of novel targeted cancer drugs. Although these agents can initially be highly …