… skeletal muscle and adipose tissues, an inhibition of hepatic PGC-1α … , muscle PGC-1α
overexpression led to insulin resistance in … tissues and has distinct and even opposite functions in …

… dysfunctions of skeletal muscle including insulin resistance (IR)… PGC-1α was associated with
mediating the protective effects … Overexpression of PGC-α is able to prevent the activation of …

… in a variety of tissues, including muscles, brain and liver [1]. … to overexpress and knockdown
PGC-1α in skeletal muscle … whereas routine exercise can have an opposite effect. In view …

… hepatic PGC1A levels are associated with insulin resistance. … opposite to that observed
following PGC1A overexpression. … al., PGC-1α overexpression results in increased hepatic fatty …

… Hepatic insulin resistance is a key factor related to many … Unlike the insulin resistance of
muscle and adipose which occur … Subsequently, 1 μg of total RNA was reverse-transcribed into …

… SIRT1 promotes deacetylation of liver kinase B1, which triggers … adipose tissue, PGC-1α
overexpression resulted in brown … and insulin resistance. Theoretically, targeted regulation of …

… The total RNA (1 μg) was reverse transcribed into first-strand … skeletal muscle MOTS-c
expression through a PGC-1α-… SIRT1 overexpression plasmid and found that SIRT1, PGC-1α and …

… to skeletal muscle metabolism and insulin sensitivity in obese … Overexpression of adiponectin
receptors potentiates the anti-… training improves liver and adipose tissue insulin sensitivity. …

… in muscle appearance with PGC-1α overexpression in mouse … On the contrary, the substrate
and pH conditions observed in … skeletal muscle insulin sensitivity in muscle-specific PGC-1α …

… , such as brown fat, liver, and skeletal muscle. Many studies … may reverse the effect of the
siRNA on the PGC-1α pathway by … Researchers have shown that the overexpression of PGC-1α …