Targeting Wnt signaling through small molecules in governing stem cell fate and diseases

A Banerjee, G Jothimani, SV Prasad… - … Metabolic & Immune …, 2019 - ingentaconnect.com
… the core molecular mechanisms by which the stem cells regenerate and differentiate. … stem
cell fate via targeting the Wnt signaling pathway. Keywords: Wnt ligands, Wnt inhibitors, Wnt

β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells

AB Rosenbloom, M Tarczyński, N Lam… - Proceedings of the …, 2020 - National Acad Sciences
Wnt signaling both in vitro (8) and in vivo (9). On an organismal behavior timescale, running
modulates Wnt signaling, … that involves Wnt signaling (10), and oscillatory Wnt signaling in …

Wnt signaling: from mesenchymal cell fate to lipogenesis and other mature adipocyte functions

DP Bagchi, OA MacDougald - Diabetes, 2021 - Am Diabetes Assoc
… Roles of this pathway in mesenchymal stem cell fate determination and differentiation … Wnt
signaling is a significant endogenous inhibitor of adipogenesis and promoter of other cell fates

WNT signaling in stem cells: A look into the non-canonical pathway

MA Sarabia-Sánchez, M Robles-Flores - Stem Cell Reviews and Reports, 2024 - Springer
… role of non-canonical Wnt signaling in embryonic development, and we focus on Embryonic
Stem Cell (ESC) differentiation [50]. Retinoic acid (RA) reduces stem cell marker Lrh-1 (Liver …

A novel self-organizing embryonic stem cell system reveals signaling logic underlying the patterning of human ectoderm

G Britton, I Heemskerk, R Hodge, AA Qutub… - …, 2019 - journals.biologists.com
… embryonic stem cells self-organize to form robust and … WNT signaling is a crucial control
parameter, and that cells sense relative levels of BMP and WNT signaling in making fate

Wnt signaling regulates the proliferation potential and lineage commitment of human umbilical cord derived mesenchymal stem cells

G Jothimani, R Di Liddo, S Pathak, M Piccione… - Molecular biology …, 2020 - Springer
… the Wnt signaling in MSCs is controversial. Thus, this study tests the hypothesis … Wnts
regulate the lineage commitments in human umbilical cord (UC) derived mesenchymal stem cells (…

Notch signaling in mammalian intestinal stem cells: determining cell fate and maintaining homeostasis

S Liang, X Li, X Wang - Current stem cell research & therapy, 2019 - ingentaconnect.com
… While bioinformatics and comparative genomics analyses showed that the Notch ligand
Jag1 is a downstream target gene of Wnt signaling, blocking Wnt signaling in mice and LS174T …

Role of β-catenin activation levels and fluctuations in controlling cell fate

E Pedone, L Marucci - Genes, 2019 - mdpi.com
… pathway, and the focus of this review, is the canonical Wnt signaling; β-catenin, the pathway
… when studying hematopoietic stem cell (HSC) differentiation in the presence of varying Wnt/β…

A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

I Martyn, AH Brivanlou, ED Siggia - Development, 2019 - journals.biologists.com
… We have also shown that BMP4 induces WNT ligand and that this WNT is necessary for the
… have shown that WNT signaling is sufficient to induce the self-organization of a human PS at …

GATA4 regulates mesenchymal stem cells via direct transcriptional regulation of the WNT signalosome

AB Khalid, J Pence, S Suthon, J Lin… - Bone, 2021 - Elsevier
… that WNT signaling would be down-regulated, due to the role of WNT signaling in stem cells
… Bone marrow cells from WT and Gata4 Prx-cKO mice were cultured in mouse MesenCult …