[HTML][HTML] SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells
S Mukherjee, DM Luedeke, L McCoy, M Iwafuchi… - Cell reports, 2022 - cell.com
… pathway, and they provide important insights into how the combination of TCFs and
lineage-specific SOX TFs regulate distinct transcriptional programs downstream of WNT signaling …
lineage-specific SOX TFs regulate distinct transcriptional programs downstream of WNT signaling …
[HTML][HTML] Mitochondria as signaling organelles control mammalian stem cell fate
RP Chakrabarty, NS Chandel - Cell stem cell, 2021 - cell.com
… to support stem cell … as signaling organelles dictate stem cell fate and function. In this
review, we focus on key conceptual ideas on how mitochondria control mammalian stem cell fate …
review, we focus on key conceptual ideas on how mitochondria control mammalian stem cell fate …
[HTML][HTML] Stem cell signaling pathways in the small intestine
T Takahashi, A Shiraishi - International journal of molecular sciences, 2020 - mdpi.com
… The central role of Wnt signaling is highlighted by Wnt-dependent expression … , Wnt signaling
mediates secretory cell fate decision. Specifically, Wnt signaling plays a role in Paneth cell …
mediates secretory cell fate decision. Specifically, Wnt signaling plays a role in Paneth cell …
[HTML][HTML] Wnt signaling activation: Targets and therapeutic opportunities for stem cell therapy and regenerative medicine
… tools for studying Wnt signaling in various biological … the Wnt signaling cascades happening
in human Wnt-related diseases, which is a prerequisite to the development of Wnt signaling-…
in human Wnt-related diseases, which is a prerequisite to the development of Wnt signaling-…
[HTML][HTML] Deciphering role of Wnt signalling in cardiac mesoderm and cardiomyocyte differentiation from human iPSCs: four-dimensional control of Wnt pathway for …
… Differentiation of cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs)
is critically dependent upon the regulation of the Wnt signaling pathway. The mechanisms …
is critically dependent upon the regulation of the Wnt signaling pathway. The mechanisms …
[HTML][HTML] Wnt4 from the niche controls the mechano-properties and quiescent state of muscle stem cells
S Eliazer, JM Muncie, J Christensen, X Sun, RS D'Urso… - Cell stem cell, 2019 - cell.com
… -acting factors that control quiescence and the transition toward activation. The Wnt signaling
pathway has been demonstrated to act as a conserved regulator of stem cell function via …
pathway has been demonstrated to act as a conserved regulator of stem cell function via …
The Wnt pathway: from signaling mechanisms to synthetic modulators
… function of Wnt signaling, focusing on the β-… of Wnt signaling leads to loss of cycling stem
cells in the mouse intestine and to death shortly after birth (35). These tissue-specific stem cells …
cells in the mouse intestine and to death shortly after birth (35). These tissue-specific stem cells …
Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells
N Rajakulendran, KJ Rowland… - Genes & …, 2019 - genesdev.cshlp.org
… Strikingly, we show that dual inhibition of Notch and Wnt signaling in ASCL1 hi GSCs
accelerates the timing and extent of neuronal differentiation, pointing to new combinatorial …
accelerates the timing and extent of neuronal differentiation, pointing to new combinatorial …
[HTML][HTML] Time-integrated BMP signaling determines fate in a stem cell model for early human development
… follow signaling histories linked to cell fate in large numbers of human pluripotent stem cells
(… , we discover that measured BMP signaling history correlates strongly with fate in individual …
(… , we discover that measured BMP signaling history correlates strongly with fate in individual …
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates
… , we identified the Wnt/PCP pathway as a new niche signal that determines stem cell fate.
We propose that a switch from Wnt/β-catenin to non-canonical Wnt/PCP signalling induces PC …
We propose that a switch from Wnt/β-catenin to non-canonical Wnt/PCP signalling induces PC …