[HTML][HTML] Small molecules for mesenchymal stem cell fate determination

YH Cheng, JC Dong, Q Bian - World Journal of Stem Cells, 2019 - ncbi.nlm.nih.gov
… (Fzd) receptors, the canonical Wnt signaling pathway is activated, and … Activation of the
canonical Wnt signaling pathway … the osteogenic cell fate of MSCs via the Wnt signaling pathway …

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

JP Russell, X Lim, A Santambrogio, V Yianni… - Elife, 2021 - elifesciences.org
… properties yet contributing minimally to turnover and repair, the necessity for such classical
stem cells is questioned. Here we show that WNT signalling is required for postnatal pituitary …

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

L Novellasdemunt, A Kucharska, C Jamieson… - The EMBO …, 2020 - embopress.org
… multiple cellular processes such as stem cell maintenance and cell fate decision (Clevers &
Wnt signalling controls the level of the key effector β-catenin for signal transduction. This is …

Interplay between mechanics and signalling in regulating cell fate

H De Belly, EK Paluch, KJ Chalut - Nature Reviews Molecular Cell …, 2022 - nature.com
… This study exemplifies the impact of forces on stem cell fate. Similar to other … cellcell
adhesion, β-catenin, Wnt signalling and mechanosensitivity, because β-catenin/Wnt signalling has …

Dual inhibition of BMP and WNT signals promotes pancreatic differentiation from human pluripotent stem cells

M Tan, L Jiang, Y Li, W Jiang - Stem cells international, 2019 - Wiley Online Library
… which are usually driven by the WNT signaling pathway, we had … WNT signal pathways.
Our data suggested that BMP inhibitors led to lower WNT activity and suppressed WNT signaling

Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

W Liang, P Han, EH Kim, J Mak, R Zhang… - Stem Cells, 2020 - academic.oup.com
… dictated by Wnt signaling which strongly influences pluripotent stem cell-derived, Flk1 + /PdgfR-α
+ cardiac mesodermal cells to differentiate into either SAN-like pacemaker cells or …

Wnt signaling is required for the maintenance of human limbal stem/progenitor cells in vitro

S González, D Oh, ER Baclagon… - … & visual science, 2019 - iovs.arvojournals.org
… inhibitor DKK using IIIC3 enhances the proliferation of LSCs in a dose-dependent manner,
while inhibition of Wnt signaling using IC15 reduces the stem cell proliferation and quantity. …

TGF-β signaling in cell fate control and cancer

Y Yu, XH Feng - Current opinion in cell biology, 2019 - Elsevier
… For example, Activin/Nodal signaling not only is necessary to maintain pluripotency in
human pluripotent stem cells (hPSCs), but it also cooperates with BMP and WNT pathways to …

Cell fate specification and differentiation in the adult mammalian intestine

J Beumer, H Clevers - Nature reviews Molecular cell biology, 2021 - nature.com
… of cues that control cell fate decisions and the diverse functions of the … of stem cells into
Paneth cells. It remains unclear how Hippo signalling restricts the activity of WNT signalling. …

Tissue mechanics in stem cell fate, development, and cancer

MK Hayward, JM Muncie, VM Weaver - Developmental cell, 2021 - cell.com
… In this review, we link these forces in directing stem cell behavior during development and
tissue-specific differentiation. We review how dysregulation of tissue-level force increases risk …