[HTML][HTML] Small molecules for mesenchymal stem cell fate determination
… (Fzd) receptors, the canonical Wnt signaling pathway is activated, and … Activation of the
canonical Wnt signaling pathway … the osteogenic cell fate of MSCs via the Wnt signaling pathway …
canonical Wnt signaling pathway … the osteogenic cell fate of MSCs via the Wnt signaling pathway …
Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells
… properties yet contributing minimally to turnover and repair, the necessity for such classical
stem cells is questioned. Here we show that WNT signalling is required for postnatal pituitary …
stem cells is questioned. Here we show that WNT signalling is required for postnatal pituitary …
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
L Novellasdemunt, A Kucharska, C Jamieson… - The EMBO …, 2020 - embopress.org
… multiple cellular processes such as stem cell maintenance and cell fate decision (Clevers &
… Wnt signalling controls the level of the key effector β-catenin for signal transduction. This is …
… Wnt signalling controls the level of the key effector β-catenin for signal transduction. This is …
Interplay between mechanics and signalling in regulating cell fate
… This study exemplifies the impact of forces on stem cell fate. Similar to other … cell–cell
adhesion, β-catenin, Wnt signalling and mechanosensitivity, because β-catenin/Wnt signalling has …
adhesion, β-catenin, Wnt signalling and mechanosensitivity, because β-catenin/Wnt signalling has …
Dual inhibition of BMP and WNT signals promotes pancreatic differentiation from human pluripotent stem cells
M Tan, L Jiang, Y Li, W Jiang - Stem cells international, 2019 - Wiley Online Library
… which are usually driven by the WNT signaling pathway, we had … WNT signal pathways.
Our data suggested that BMP inhibitors led to lower WNT activity and suppressed WNT signaling …
Our data suggested that BMP inhibitors led to lower WNT activity and suppressed WNT signaling …
Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
… dictated by Wnt signaling which strongly influences pluripotent stem cell-derived, Flk1 + /PdgfR-α
+ cardiac mesodermal cells to differentiate into either SAN-like pacemaker cells or …
+ cardiac mesodermal cells to differentiate into either SAN-like pacemaker cells or …
Wnt signaling is required for the maintenance of human limbal stem/progenitor cells in vitro
S González, D Oh, ER Baclagon… - … & visual science, 2019 - iovs.arvojournals.org
… inhibitor DKK using IIIC3 enhances the proliferation of LSCs in a dose-dependent manner,
while inhibition of Wnt signaling using IC15 reduces the stem cell proliferation and quantity. …
while inhibition of Wnt signaling using IC15 reduces the stem cell proliferation and quantity. …
TGF-β signaling in cell fate control and cancer
Y Yu, XH Feng - Current opinion in cell biology, 2019 - Elsevier
… For example, Activin/Nodal signaling not only is necessary to maintain pluripotency in
human pluripotent stem cells (hPSCs), but it also cooperates with BMP and WNT pathways to …
human pluripotent stem cells (hPSCs), but it also cooperates with BMP and WNT pathways to …
Cell fate specification and differentiation in the adult mammalian intestine
… of cues that control cell fate decisions and the diverse functions of the … of stem cells into
Paneth cells. It remains unclear how Hippo signalling restricts the activity of WNT signalling. …
Paneth cells. It remains unclear how Hippo signalling restricts the activity of WNT signalling. …
Tissue mechanics in stem cell fate, development, and cancer
… In this review, we link these forces in directing stem cell behavior during development and
tissue-specific differentiation. We review how dysregulation of tissue-level force increases risk …
tissue-specific differentiation. We review how dysregulation of tissue-level force increases risk …