[HTML][HTML] Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesoderm fate acquisition

BA Kinney, A Al Anber, RH Row, YJ Tseng… - Cell reports, 2020 - cell.com
… the mesoderm-inducing canonical Wnt signaling pathway. When Wnt signaling is inhibited
in Sox2-expressing cells trapped in the partial EMT, cells exit into the mesodermal territory …

Wnt/β-catenin signaling in neural stem cell homeostasis and neurological diseases

J Gao, Y Liao, M Qiu, W Shen - The Neuroscientist, 2021 - journals.sagepub.com
Wnt signaling is thought to control the balance of NSC proliferation and differentiation via
the transcriptional coactivator β-catenin during brain development and adult tissue …

[HTML][HTML] Wnt signaling mediates the aging-induced differentiation impairment of intestinal stem cells

H Cui, D Tang, GB Garside, T Zeng, Y Wang… - Stem Cell Reviews and …, 2019 - Springer
… Up-regulation of Wnt signaling during aging leads to impairment of muscle stem cell
Previously, we have identified Wnt signaling as a key mediator of ISC fate decision in premature …

[HTML][HTML] Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

I Heemskerk, K Burt, M Miller, S Chhabra, MC Guerra… - Elife, 2019 - elifesciences.org
… the time for making cell fate decisions. Here, we use human embryonic stem cells (hESCs) to
… , costimulation with Activin or BMP switches the dynamics of Wnt signaling from transient to …

[HTML][HTML] Principles of signaling pathway modulation for enhancing human naive pluripotency induction

J Bayerl, M Ayyash, T Shani, YS Manor, O Gafni… - Cell stem cell, 2021 - cell.com
… pluripotent stem cells (hPSCs). For example, naive human stem cell medium (NHSM)
conditions do not require the use of exogenous transgenes or feeder cells, maintain teratoma …

A comprehensive library of human transcription factors for cell fate engineering

AHM Ng, P Khoshakhlagh, JE Rojo Arias… - Nature …, 2021 - nature.com
… After constructing the Human TFome, we screened each TF for its ability to induce differentiation
of three human induced pluripotent stem cell (hiPSC) lines. Of the 290 hits, we found …

New roles for Wnt and BMP signaling in neural anteroposterior patterning

H Polevoy, YE Gutkovich, A Michaelov, Y Volovik… - EMBO …, 2019 - embopress.org
… We find that inhibition of canonical Wnt signaling or its downstream transcription factors …
spinal cord cell fate formation in an FGF‐dependent manner, while inhibiting hindbrain fates. …

Stromal control of intestinal development and the stem cell niche

G Greicius, DM Virshup - Differentiation, 2019 - Elsevier
stem cell niche As described above, multiple distinct approaches that interfere with Wnt
signaling all … Is the role of Wnt signaling in these adult stem cells to drive their proliferation or to …

Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling

S Chen, Y Zheng, X Ran, H Du, H Feng, L Yang… - Cell Research, 2021 - nature.com
… niche cells, including the Paneth cells and the stromal cells … in maintaining Wnt signaling
by secreting Wnt ligands. Notch … Notch signaling and downregulated Wnt signaling along the …

[HTML][HTML] Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance

CK Brock, ST Wallin, OE Ruiz, KM Samms… - Nature …, 2019 - nature.com
… if Wnt signaling is activated in the engulfing stem cell using a … p63-positive stem cells with
active Wnt signaling (TCF-Siam:… stem cells engulf the apoptotic bodies, activate Wnt signaling