Physiological cues involved in the regulation of adhesion mechanisms in hematopoietic stem cell fate decision
R Kulkarni, V Kale - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
… These components control the HSC fate decision through direct cell–cell interactions –
mediated via various types of adhesion molecules –, cell-ECM interactions – mediated mostly via …
mediated via various types of adhesion molecules –, cell-ECM interactions – mediated mostly via …
Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm
M Linneberg-Agerholm, YF Wong… - …, 2019 - journals.biologists.com
… Wnt signalling. However, when these pathways are activated in naïve ESCs, they differentiate
to a cell … context dependency to human ESCs, showing that activation of Nodal and Wnt …
to a cell … context dependency to human ESCs, showing that activation of Nodal and Wnt …
WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer
… In this study, we show that TNBC stem cells (TNBCSCs) constitutively upregulate PD-L1
through the activity of the WNT signaling pathway, the inhibition or activation of which …
through the activity of the WNT signaling pathway, the inhibition or activation of which …
[HTML][HTML] Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease
… cell-cell interactions in the developing human alveolar niche, showing that Wnt signaling
from … alveolar-type-2 cell identity, whereas myofibroblasts secrete the Wnt inhibitor, NOTUM, …
from … alveolar-type-2 cell identity, whereas myofibroblasts secrete the Wnt inhibitor, NOTUM, …
[HTML][HTML] 3D cell culture models demonstrate a role for FGF and WNT signaling in regulation of lung epithelial cell fate and morphogenesis
… These results indicated that the self-renewing lungosphere-forming stem cells are present
… by the division of single stem cells rather than being formed by cell aggregation, we sorted …
… by the division of single stem cells rather than being formed by cell aggregation, we sorted …
Dysregulation of the Wnt signaling pathway and synovial stem cell dysfunction in osteoarthritis development
J Huang, C Chen, C Liang, P Luo, G Xia… - Stem Cells and …, 2020 - liebertpub.com
… In conclusion, stem cells in the OA synovium were functionally abnormal and promoted
the development of OA, whereas dysregulation of the Wnt signaling pathway revealed a …
the development of OA, whereas dysregulation of the Wnt signaling pathway revealed a …
Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells
… To further investigate the implication of Wnt/β-catenin signaling in the control and protection
of the ICRs against de-methylation, we generated two Wnt signaling mutant mESC clones …
of the ICRs against de-methylation, we generated two Wnt signaling mutant mESC clones …
The Wnt pathway: An important control mechanism in bone's response to mechanical loading
RB Choi, AG Robling - Bone, 2021 - Elsevier
… Secreted Wnt signaling inhibitors antagonize Wnt signaling by … on cell surface
receptors/inhibitors and secreted inhibitors of Wnt signaling, but the real business end of Wnt …
receptors/inhibitors and secreted inhibitors of Wnt signaling, but the real business end of Wnt …
Wnt signaling and drug resistance in cancer
Z Zhong, DM Virshup - Molecular pharmacology, 2020 - ASPET
… , Wnt signaling controls axis patterning, cell fate specification, cell proliferation, and cell …
roles of Wnt signaling is to maintain the adult stem cells. Using lineage tracing strategies, the …
roles of Wnt signaling is to maintain the adult stem cells. Using lineage tracing strategies, the …
Regulation and directing stem cell fate by tissue engineering functional microenvironments: scaffold physical and chemical cues
F Xing, L Li, C Zhou, C Long, L Wu, H Lei… - Stem cells …, 2019 - Wiley Online Library
… fate by activating MAP kinase pathways and Wnt signaling [53]. In … stem cells. Therefore,
the micropatterns of scaffolds could affect the cell behavior by altering the shapes of stem cells […
the micropatterns of scaffolds could affect the cell behavior by altering the shapes of stem cells […