… These conditions are dynamically controlled based on the balance between cell cycle
activators and inhibitors. Canonical WNT signaling induces proliferation of cancer stem cells (…

… By contrast, our data show that transcriptionally active YAP in normal crypts and organoids
regulated by CCN1-integrins α v β 3 /α v β 5 signaling controls Wnt signaling and restricts ISC …

… that micropatterned human pluripotent stem cells (hPSCs) … like fates, and that the remaining
low levels of Wnt signaling correlate … is that a low level of Wnt signaling is needed for PGCLC …

… of mESCs by activating Wnt signaling [64]. Not only stem cells have the characteristics of
self-renewal and rare differentiation, but cancer stem cells also have the characteristics of …

… PI3K/AKT on one hand inhibits ERK and WNT signaling, allowing SMAD2/3 to activate
pluripotency associated target genes rather than lineage genes; on the other hand, the …

… stem cell- and patient-derived 3D organoid cultures can be employed to gain insight into the
regulatory mechanisms of Wnt signaling in … positive feedback in Wnt signaling regulation. In …

… human pluripotent stem cells can be triggered to self-organize into three-dimensional structures
that recapitulate some key spatiotemporal events of early human … potent WNT signalling …

… The use of pluripotent stem cells to model human neural crest … Is exogenous WNT signaling
required for the full 5 days? Or … Which time-points are optimal to translate the WNT signal …

… determinants of cell fate is critical both for understanding early development, and to guide
lineage commitment of pluripotent stem cells to enable the replacement of diseased cell types …

… While the role of mechanical forces in cell fate can be studied in stem cell cultures, in vitro
approaches do not provide insight into morphogenesis. Thus, understanding how mechanical …