… Runx2 expression or its activity is essential for controlling osteoblast differentiation. Runx2
activity is … Runx2, interacted with HDAC3 upon recruitment by Zfp521, leading to decreased …

… The present study hypothesized that Zfp521 attenuated OA by maintaining ECM … As a
nuclear protein, Zfp521 antagonizes Runx2 transcriptional activity in vitro and the early bone …

… of the Wnt signaling pathway and RUNX2's transcriptional activity, effectively suppressing …
ZFP521 binds to RUNX2 and recruits HDAC3 to suppress the transcriptional activity of RUNX2…

… Runx2 expression and repressed its transcriptional activity. Runx2 was involved in osteoblastic
differentiation, skeletal … Runx2 overexpression promoted CXCR7 expression and cellular …

… negatively modulates differentiation by repressing ZFP432, EBF1, and RUNX2 ( … (J and
K) Zfp521 deficiency elevates the activities of caspase 3 and caspase 7. Representative …

… 100], being capable, in turn, to antagonize the transcriptional activity of RUNX2 [101,102].
The suppressive role of HDAC3 on osteogenic differentiation by deacetylating H3 localized on …

At present, epigenetics is getting more and more attention. Epigenetics can also regulate
gene expression without changing the coding sequence of DNA, and DNA methylation and …

… by the bone-anabolic activity of 17β-estradiol in trabecular but not cortical bone following …
The BMP2 responsive transcription factor RUNX2 controls osteoblast differentiation in part …

… activity and disordered bone transformation to increase bone absorption and produce OP. …
trimethylation at the RUNX2 gene promoter to inhibit RUNX2 expression and subsequent …

… Runx2 (Citation7), and the pro-osteogenic factor Taz, while promoting Runx2 activity, inhibits
Pparγ activity … in mesenchymal stem cells Zfp423/Zfp521 interactions alter cell fate decisions…