[HTML][HTML] Selective coactivation of α7-and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid–induced synaptic dysfunction

JP Roberts, SA Stokoe, MF Sathler, RA Nichols… - Journal of Biological …, 2021 - ASBMB
… Aβ can alter neuronal signaling through interactions with nicotinic acetylcholine receptors
(nAChRs), contributing to synaptic dysfunction in AD. The three major nAChR subtypes in the …

Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid–induced Ca2+ hyperexcitation

JL Sun, SA Stokoe, JP Roberts, MF Sathler, KA Nip… - Neurobiology of …, 2019 - Elsevier
… A potential target of Aβ42 is the nicotinic acetylcholine receptor (nAChR). … We suggest
co-activation of α7 and α4β2 nAChRs is … We further reveal co-activation of α7 and α4β2 nAChRs is …

Selective Coactivation of α7 and α4β2 Nicotinic Acetylcholine Receptors Reverses Beta‐amyloid‐induced Synaptic Dysfunction Jessica P. Roberts1,2,4, Sarah A. Stokoe1,2,4, Matheus F. Sathler2, Robert A. Nichols3, Seonil …

J Roberts - The FASEB Journal, 2021 - Wiley Online Library
… Aβ can alter neuronal signaling through interactions with nicotinic acetylcholine receptors
(nAChRs), contributing to synaptic dysfunction in AD. The three major nAChR subtypes in the …

[HTML][HTML] Acetylcholine facilitates localized synaptic potentiation and location specific feature binding

Y Yang, V Booth, M Zochowski - Frontiers in Neural Circuits, 2023 - frontiersin.org
… It’s been shown that ACh signaling through M1 muscarinic ACh receptors can be well modeled
by parameterizing the maximal conductance g K s of a slow, low-threshold K + mediated …

Acetylcholine and cholinergic receptors

DA Brown - Brain and neuroscience advances, 2019 - journals.sagepub.com
… the neurotransmitter functions of acetylcholine over the 50-… nicotinic and muscarinic
acetylcholine receptors, and some brief … in knowledge about acetylcholine receptors and a …

Acetylcholine and the complex interdependence of memory and attention

AL Decker, K Duncan - Current Opinion in Behavioral Sciences, 2020 - Elsevier
… CA3 and CA1, connections between coactivated neurons are strengthened through long-term
potentiation (LTP). This co-activation and resultant strengthening allows individual …

Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders

LB Teal, RW Gould, AS Felts, CK Jones - Advances in Pharmacology, 2019 - Elsevier
… of different muscarinic acetylcholine receptor (mAChR) subtypes in the underlying
pathophysiology of schizophrenia and SUD and the potential development of selective modulators of …

[HTML][HTML] Cholinergic and adenosinergic modulation of synaptic release

D Yang, C Ding, G Qi, D Feldmeyer - Neuroscience, 2021 - Elsevier
… -called nicotinic ACh receptors and G-protein coupled muscarinic ACh receptors. In contrast,
… In addition, co-activation of β-adrenergic and M 1 muscarinic receptor can boost short-term …

[HTML][HTML] Muscarinic receptors in developmental axonal competition at the neuromuscular junction

J Tomàs, MA Lanuza, MM Santafé… - Molecular …, 2023 - Springer
… In recent years, we have studied by immunohistochemistry, intracellular recording, and
western blotting the role of the muscarinic acetylcholine receptors (mAChRs; M 1 , M 2 , and M 4 …

Muscarinic receptors, from synaptic plasticity to its role in network activity

DF De Sevilla, A Núñez, W Buño - Neuroscience, 2021 - Elsevier
Acetylcholine acting via metabotropic receptors plays a key role in learning and memory
by … However, a recent overall view of the effects of muscarinic acetylcholine receptors (mAChRs) …