… acquired resistance is based on temporal and objectively measurable criteria, it is likely that
what we call “acquired resistance… the “intrinsic resistance”) and new resistance mechanisms …

… Acquired resistance to immunotherapy is an emerging issue, especially as the indications
… clinical outcomes of acquired resistance in non-small-cell lung cancers and explores future …

… mechanisms, we defined the sensitivity of a panel of KRAS G12C–mutant lung cancer cell
… acquired resistance to AMG510 and the underlying resistance mechanisms were analyzed. …

… is associated with acquired resistance to EGFR TKIs, and that AURKB constitutes a potential
target in NSCLC progressing to anti-EGFR therapy and not carrying resistance mutations. …

… –small-cell lung cancer, 10 with colorectal cancer, and 1 with … This study focused on acquired
resistance mechanisms in … Mechanisms of acquired resistance to sotorasib are currently …

… mechanisms of acquired osimertinib resistance in EGFR mutant lung cancer using multi-…
surgeries of pre- and post-osimertinib-resistant tumors as well as metastases at rapid autopsy. …

… We investigated the VAF of resistance mutations in CTCs from 14 ALK-rearranged patients
… acquired resistance to crizotinib with the exception of P4 who developed primary resistance …

… lung malignancy. Indeed, the clinical success of these TKIs constitutes a critical milestone
in targeted cancer … of EGFR mutation-positive non-small cell lung cancer (NSCLC). The first-…

… )-mutant non-small-cell lung cancer (NSCLC) with MET overexpression (immunohistochemistry
[IHC]2+ or IHC3+) or MET amplification having acquired resistance to EGFR inhibition. …

… and small insertions within the kinase domain are common in lung cancer. For these reasons
EGFR and its preferred heterodimer partner, HER2/ERBB2, became popular targets of anti-…