… associated with acute hepatotoxicity in immunocompromised … acute hepatotoxicity, have
largely limited clinical application. … relationship between AdVs and hepatotoxicity in terms of …

… to the acute DILI and chronic liver diseases when treated by hepatotoxic xenobiotics. The
global market for re-construction of 3D liver models with associated hepatotoxicity testing has a …

… Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the … to
be clinically useful. However, most of the discussed mechanisms and the clinical application are …

… animal models of hepatotoxicity, where chemical-… for acute and chronic liver disease has
been advised in liver cell transplantation, but the limited availability of hepatocytes for clinical …

… during drug development, pre-clinical research, and clinical treatment. If not properly treated…
acute liver failure or even death. Thus, utilization of the convenient in vitro hepatotoxicity …

… all acute liver failure cases in the United States and in many other western countries (Lee,
2013). Despite the clinical significance of APAP hepatotoxicity… would limit clinical application at …

… Application of the DILIsym model to predict hepatotoxicity. Extrahepatocyte and intrahepatocyte
exposure to study drug is predicted by physiologically based pharmacokinetic modeling (…

… for its clinical applications [10, 11]. These drawbacks restrict the further application of the …
stimulated by experimental animal models resulted from hepatotoxic chemical drugs, such as …

… clinical manifestations and its features may resemble any known acute and/or chronic liver
disease (such as acute … known to cause dose-dependent hepatotoxicity. The majority of DILI …

… number of studies about clinical trials and preclinical experiments of bioartificial liver (BAL)
support systems for treating patients and large animal models with acute liver failure. We …