… acute kidney injury or reflect normal physiology. In this secondary analysis of the Sapphire
study, we examined biomarkers of cell cycle arrest … severe acute kidney injury (Kidney Disease…

… signaling to cause tubular epithelial cell death and AKI via the G1 cell cycle arrest mechanism.
This is further confirmed in Smad3 knockout mice and cells in which deletion of Smad3 …

… Their effects result in G1 cell-cycle arrest for a short period to avoid cell division when cells
… Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. …

… sepsis, renal epithelial cells undergo G1 cell cycle arrest to prevent potential damage to DNA
during replication. TIMP-2 and IGFBP7 are 2 proteins expressed during cell cycle arrest. In …

… kidneys, we compared the degree of cell cycle arrest … cell cycle arrest marker, TIMP-2 lasted
longer than that of pH3, a marker for G2-M and these results suggest that G1 cell cycle arrest …

… . demonstrated a causal association between cell cycle arrest and fibrosis [93]. … cell cycle
events could be responsible for repair, cell cycle arrest could determine the progression of injury…

… such energy requirements induces cell cycle arrest presumably to prevent a … cell cycle
arrest was associated with kidney injury and that recovery of renal function paralleled cell cycle …

… is characterized by abrupt decline of kidney function. Till now, … , programmed cell death, and
cell cycle in the injury and repair … in inflammation, cell death and cell cycle, this review aimed …

… those of the control group, and cell cycle arrest was improved. In conclusion, … renal function
and histological damage, inhibited the inflammation and apoptosis processes in the kidney, …

… Acute kidney injury (AKI) is a major kidney disease with poor clinical outcome. Besides its
acute … and subsequent kidney repair, and thus modulation of tubular cell cycle arrest provides …