A magic drug target: Androgen receptor

D Li, W Zhou, J Pang, Q Tang, B Zhong… - Medicinal research …, 2019 - Wiley Online Library
… Such AR ligands were defined as selective androgen receptor modulators (SARMs).11
Obviously, AR is definitely a very interesting drug target, and different types of AR ligands (…

Ginsenoside Rb1 inhibits vascular calcification as a selective androgen receptor modulator

M Nanao-Hamai, BK Son, A Komuro, Y Asari… - European Journal of …, 2019 - Elsevier
… efficiency of androgen receptor siRNA, we confirmed androgen receptor expression by … of
androgen receptor siRNA on Gas6 transcriptional activity in human VSMC, androgen receptor

[HTML][HTML] Role of androgen receptor in prostate cancer: a review

K Fujita, N Nonomura - The world journal of men's health, 2019 - synapse.koreamed.org
Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding domain…

[HTML][HTML] Androgen receptor signaling in the development of castration-resistant prostate cancer

Q Feng, B He - Frontiers in oncology, 2019 - frontiersin.org
… to the androgen receptor with … androgens bind to the androgen receptor with very differing
kinetics (11, 12). The rate of dissociation for dihydrotestosterone from the androgen receptor is …

Androgen receptor expression in breast cancer: Implications on prognosis and treatment, a brief review

N Jahan, C Jones, RL Rahman - Molecular and Cellular Endocrinology, 2021 - Elsevier
… Selective androgen receptor modulators (SARMs) bind to the AR and exert varying agonist
… Selective androgen receptor modulators Selective androgen receptor modulators (SARMs) …

[HTML][HTML] An overview of next-generation androgen receptor-targeted therapeutics in development for the treatment of prostate cancer

ML Mohler, A Sikdar, S Ponnusamy, DJ Hwang… - International journal of …, 2021 - mdpi.com
… Panel B: Cartoon model of a crystal structure of a selective androgen receptor modulator (…
Panel B: Cartoon model of a crystal structure of a selective androgen receptor modulator (…

[HTML][HTML] Eighty years of targeting androgen receptor activity in prostate cancer: the fight goes on

E Estébanez-Perpiñá, CL Bevan, IJ McEwan - Cancers, 2021 - mdpi.com
… for developing “selective androgen receptor modulators” and novel … receptor modulators
may also be of value for the treatment of emerging other conditions such as androgenic

[HTML][HTML] Androgen receptor in breast cancer—clinical and preclinical research insights

A Anestis, I Zoi, AG Papavassiliou, MV Karamouzis - Molecules, 2020 - mdpi.com
… The androgen receptor is expressed in more than 70% of primary breast cancers; usually,
its expression is correlated to ERα and PgR. AR prevalence is higher in ERα-positive early …

Molecules targeting the androgen receptor (AR) signaling axis beyond the AR‐Ligand binding domain

NGRD Elshan, MB Rettig… - Medicinal research reviews, 2019 - Wiley Online Library
… The androgen receptor (AR) and … androgen receptor (AR) is a ligand-activated DNA-binding
transcription factor of 110 kDa molecular weight, which facilitates the expression of androgen

[HTML][HTML] Current status and future perspectives of androgen receptor inhibition therapy for prostate cancer: a comprehensive review

TJ Kim, YH Lee, KC Koo - Biomolecules, 2021 - mdpi.com
… The androgen receptor (AR) is one of the main components in the development and
progression of prostate cancer (PCa), and treatment strategies are mostly directed toward …