Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases

A Otsuki, M Yamamoto - Archives of pharmacal research, 2020 - Springer
… The CNC family of transcription factors, including NRF2, form heterodimers with small Maf
(… as antioxidant response element, electrophile response element, or NF-E2-binding element. …

Direct and specific functional evaluation of the Nrf2 and MafG heterodimer by introducing a tethered dimer into small Maf-deficient cells

F Katsuoka, A Otsuki, M Takahashi, S Ito… - … and Cellular Biology, 2019 - Am Soc Microbiol
… A group of cytoprotective genes is regulated by heterodimers composed of the cap’n’collar
(… small Maf (sMaf) proteins (MafF, MafG, or MafK) through the antioxidant response element (…

[HTML][HTML] Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

S Liu, J Pi, Q Zhang - Redox biology, 2022 - Elsevier
… The NRF2-sMaf heterodimer recognizes specific antioxidant response elements (ARE) in …
), which is masked upon NRF2 heterodimerization with MafG, a small Maf protein, via the ZIP–…

Target gene diversity of the Nrf1-MafG transcription factor revealed by a tethered heterodimer

F Katsuoka, A Otsuki, N Hatanaka… - … and Cellular Biology, 2022 - Am Soc Microbiol
… family form heterodimers with small Maf (sMaf) … heterodimers has been referred to by various
names, such as the NF-E2-binding element (Citation16), the antioxidant response element (…

Oxidative stress and cancer heterogeneity orchestrate NRF2 roles relevant for therapy response

K Gall Trošelj, M Tomljanović, M Jaganjac… - Molecules, 2022 - mdpi.com
… for transcription of Antioxidant Response Element (ARE)-… small MAF (sMAF) protein to form
NRF2-sMAF heterodimers. … NRF2-sMAF heterodimer formation ensures binding of NRF2 …

Structural basis of transcription regulation by CNC family transcription factor, Nrf2

T Sengoku, M Shiina, K Suzuki, K Hamada… - Nucleic acids …, 2022 - academic.oup.com
… (CsMBEs) (3), also called antioxidant responsive elements (… bind to sequences called
Maf-responsive elements (MAREs) … We propose that the high affinity of CNC–sMaf heterodimers

The Functional Significance of McMafF_G_K in Molluscs: Implications for Nrf2-Mediated Oxidative Stress Response

R Yao, L Qiu, L Zhu, X Chen, J Zhai, W Wang… - International Journal of …, 2023 - mdpi.com
… with antioxidant response elements (ARE) [5,7]. Its downstream target genes include genes
encoding antioxidant … process of the Nrf2/Maf heterodimer for activating the antioxidant stress …

The role and regulation of Maf proteins in cancer

Y Deng, L Lu, H Zhang, Y Fu, T Liu, Y Chen - Biomarker Research, 2023 - Springer
responsive elements (TREs) or cAMP responsive elements (CREs) [15, 16]. Homodimers and
heterodimers are … , which is also known as the Maf recognition element (MARE). This motif …

[PDF][PDF] … FACTOR ERYTHROID 2 RELATED FACTOR-1 (NRF1) MEDIATES CELASTROL-INDUCED GENE REGULATION, DEPENDING ON ITS HETERODIMERIC …

A Ahadiabhari - 2023 - harvest.usask.ca
heterodimer with small MAFs or other bZIP proteins, as upon binding to an antioxidant
response element (ARE) this heterodimer … of NRF1 heterodimerization with small MAF proteins. …

Oxidative stress and cancer: Role of the Nrf2-antioxidant response element signaling pathway

M Ruwali, R Shukla - Handbook of oxidative stress in cancer: Mechanistic …, 2022 - Springer
… After gaining entry into the nucleus, Nrf2 forms a heterodimer with cotranscription factor
Maf and binds to ARE leading to the induction of a plethora of cytoprotective genes which …