Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases
A Otsuki, M Yamamoto - Archives of pharmacal research, 2020 - Springer
… The CNC family of transcription factors, including NRF2, form heterodimers with small Maf
(… as antioxidant response element, electrophile response element, or NF-E2-binding element. …
(… as antioxidant response element, electrophile response element, or NF-E2-binding element. …
Direct and specific functional evaluation of the Nrf2 and MafG heterodimer by introducing a tethered dimer into small Maf-deficient cells
F Katsuoka, A Otsuki, M Takahashi, S Ito… - … and Cellular Biology, 2019 - Am Soc Microbiol
… A group of cytoprotective genes is regulated by heterodimers composed of the cap’n’collar
(… small Maf (sMaf) proteins (MafF, MafG, or MafK) through the antioxidant response element (…
(… small Maf (sMaf) proteins (MafF, MafG, or MafK) through the antioxidant response element (…
[HTML][HTML] Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
S Liu, J Pi, Q Zhang - Redox biology, 2022 - Elsevier
… The NRF2-sMaf heterodimer recognizes specific antioxidant response elements (ARE) in …
), which is masked upon NRF2 heterodimerization with MafG, a small Maf protein, via the ZIP–…
), which is masked upon NRF2 heterodimerization with MafG, a small Maf protein, via the ZIP–…
Target gene diversity of the Nrf1-MafG transcription factor revealed by a tethered heterodimer
F Katsuoka, A Otsuki, N Hatanaka… - … and Cellular Biology, 2022 - Am Soc Microbiol
… family form heterodimers with small Maf (sMaf) … heterodimers has been referred to by various
names, such as the NF-E2-binding element (Citation16), the antioxidant response element (…
names, such as the NF-E2-binding element (Citation16), the antioxidant response element (…
Oxidative stress and cancer heterogeneity orchestrate NRF2 roles relevant for therapy response
… for transcription of Antioxidant Response Element (ARE)-… small MAF (sMAF) protein to form
NRF2-sMAF heterodimers. … NRF2-sMAF heterodimer formation ensures binding of NRF2 …
NRF2-sMAF heterodimers. … NRF2-sMAF heterodimer formation ensures binding of NRF2 …
Structural basis of transcription regulation by CNC family transcription factor, Nrf2
T Sengoku, M Shiina, K Suzuki, K Hamada… - Nucleic acids …, 2022 - academic.oup.com
… (CsMBEs) (3), also called antioxidant responsive elements (… bind to sequences called
Maf-responsive elements (MAREs) … We propose that the high affinity of CNC–sMaf heterodimers …
Maf-responsive elements (MAREs) … We propose that the high affinity of CNC–sMaf heterodimers …
The Functional Significance of McMafF_G_K in Molluscs: Implications for Nrf2-Mediated Oxidative Stress Response
R Yao, L Qiu, L Zhu, X Chen, J Zhai, W Wang… - International Journal of …, 2023 - mdpi.com
… with antioxidant response elements (ARE) [5,7]. Its downstream target genes include genes
encoding antioxidant … process of the Nrf2/Maf heterodimer for activating the antioxidant stress …
encoding antioxidant … process of the Nrf2/Maf heterodimer for activating the antioxidant stress …
The role and regulation of Maf proteins in cancer
Y Deng, L Lu, H Zhang, Y Fu, T Liu, Y Chen - Biomarker Research, 2023 - Springer
… responsive elements (TREs) or cAMP responsive elements (CREs) [15, 16]. Homodimers and
heterodimers are … , which is also known as the Maf recognition element (MARE). This motif …
heterodimers are … , which is also known as the Maf recognition element (MARE). This motif …
[PDF][PDF] … FACTOR ERYTHROID 2 RELATED FACTOR-1 (NRF1) MEDIATES CELASTROL-INDUCED GENE REGULATION, DEPENDING ON ITS HETERODIMERIC …
A Ahadiabhari - 2023 - harvest.usask.ca
… heterodimer with small MAFs or other bZIP proteins, as upon binding to an antioxidant
response element (ARE) this heterodimer … of NRF1 heterodimerization with small MAF proteins. …
response element (ARE) this heterodimer … of NRF1 heterodimerization with small MAF proteins. …
Oxidative stress and cancer: Role of the Nrf2-antioxidant response element signaling pathway
M Ruwali, R Shukla - Handbook of oxidative stress in cancer: Mechanistic …, 2022 - Springer
… After gaining entry into the nucleus, Nrf2 forms a heterodimer with cotranscription factor
Maf and binds to ARE leading to the induction of a plethora of cytoprotective genes which …
Maf and binds to ARE leading to the induction of a plethora of cytoprotective genes which …
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