… To understand the significance of RV as related to the persistence of HIV infection, we
characterized the dynamics of RV sequence variants among plasma viruses over nearly a decade …

… (NGS), virus variants present at low frequencies within the virus population of individuals can
… or cutoffs for detecting low-abundance variants, and specific strengths and limitations [11]. …

… antiretroviral therapy (ART) and efforts to develop a cure for HIV-1 infection include
characterization of the reservoirs that sustain viral … post-ATI viremia contains virus variants with a …

… transcriptase inhibitors (NNRTI)-based antiretroviral treatment (ART) is increasing in low-…
to participants with wild-type viruses, those who only harbored minority variants, either 2–9…

… In addition, in patient 2, the WT L31 was detected in 21% of viral variants by deep sequencing,
whereas only L31M had been reported by population sequencing (Fig. 2D). These results …

… treatment [18], although their efficacy can be dramatically impacted by the currently circulating
viral variant … will no longer harbor the contagious virus, and instead of antiviral therapy, the …

… who had not previously received antiretroviral treatment (ART) and … of HIV-1, 3 a high viral
load and low CD4 cell count, 5 … variants — in this case, variants carrying R263K and G118R. …

… The aim of HIV treatments is to reduce viral loads to undetectable levels. Antiretroviral drugs
act by different mechanisms of action, while targeting various steps in the HIV replication …

… Successful treatment with antiretroviral drugs suppresses viral load and interrupts the … this
viral variant as the “VB variant” (for virulent subtype B), to individuals infected with this variant …

The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy
… of proviral variants in the reservoir were most closely related to viral variants from the latest …