Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis

L Su, P Pan, P Yan, Y Long, X Zhou, X Wang, R Zhou… - Scientific reports, 2019 - nature.com
… lymphocyte apoptosis and inflammatory responses and that … prognostic prediction of patients
with sepsis or septic shock. … of sepsis, and as vimentin plays a role in lymphocyte apoptosis, …

Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms

A Marques, C Torre, R Pinto, B Sepodes… - Journal of Clinical …, 2023 - mdpi.com
… UTI is a trypsin inhibitor found in human urine with demonstrated anti-inflammatory and
anti-apoptotic properties [96,97]. According to a recent meta-analysis, combination therapy may …

Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
… In the third International Consensus for Sepsis and Septic Shock, sepsis was clinically defined
… However, accelerated apoptosis resulted in inflammation resolution in several preclinical …

Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic …

M Gu, XL Mei, YN Zhao - Neurotoxicity research, 2021 - Springer
… subsequent to septic shocks. Even a short-term apoptosis associated with sepsis may also
lead to … induces cellular metabolism and energy production as a key cause for inflammation, …

Oxidant/antioxidant status is impaired in sepsis and is related to anti-apoptotic, inflammatory, and innate immunity alterations

M Miliaraki, P Briassoulis, S Ilia, K Michalakakou… - Antioxidants, 2022 - mdpi.com
… This study included 145 patients with sepsis/septic shock (S) (85 males (59%) and 60
females (41%), 112 patients with non-infectious critical illness (I) (80% males), and 89 healthy …

Emerging mechanisms of immunocoagulation in sepsis and septic shock

D Tang, H Wang, TR Billiar, G Kroemer, R Kang - Trends in immunology, 2021 - cell.com
… mitochondrial DNA in septic shock and postsurgical systemic inflammation and its influence
… in various types of cell death (eg, apoptosis, necroptosis, pyroptosis, and ferroptosis) and is …

Hyperinflammation, apoptosis, and organ damage

FA Kuypers - Experimental Biology and Medicine, 2022 - journals.sagepub.com
Sepsis and septic shock are the important causes of morbidity and lethality resulting from
the … The CS and immune cell apoptosis results in uncontrolled, systemic inflammation in …

Oxidative stress and endothelial dysfunction in sepsis and acute inflammation

J Joffre, J Hellman - Antioxidants & redox signaling, 2021 - liebertpub.com
inflammation, and therapeutic avenues targeting OS and endothelial alterations during septic
shock… about 20% the EC apoptosis induced by plasma from patients with septic shock (78). …

Apoptotic cell therapy for cytokine storm associated with acute severe sepsis

N Karbian, A Abutbul, R El-Amore, R Eliaz… - Cell Death & …, 2020 - nature.com
Apoptotic cells themselves are major contributors to the “non-inflammatory” nature of the …
In sepsis and septic shock patients, upregulation of many cytokines, including IL-1β, IL-6, IL-…

Immune profile of patients‑a new approach in management of sepsis and septic shock?

A Bacârea, O Coman, VC Bacârea… - Experimental and …, 2024 - spandidos-publications.com
inflammation, termed systemic inflammatory response syndrome, and the presence of a known
infection. It can evolve to septic shock, … in severe sepsis/shock modulates the apoptosis of …