H3K36me2/3 binding and DNA binding of the DNA methyltransferase DNMT3A PWWP domain both contribute to its chromatin interaction

M Dukatz, K Holzer, M Choudalakis, M Emperle… - Journal of molecular …, 2019 - Elsevier
DNA suggests a combined binding to H3K36me2/3 and DNA. We show here that the DNMT3A
PWWP domain binds to DNA … and specificity of methylated H3K36 and DNA binding of the …

Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases

S Tajima, I Suetake, K Takeshita, A Nakagawa… - DNA Methyltransferases …, 2022 - Springer
… Rett syndrome is known to be caused mainly by a mutation in the MeCP2 gene, of which
the translation product specifically binds to methylated DNA and is a component of the …

Methods for analysis of specific DNA methylation status

MJ Pajares, C Palanca-Ballester, R Urtasun… - Methods, 2021 - Elsevier
… In the last group, proteins with methylation binding domains or antibodies against methyl
cytosines are used to recognize methylated DNA. In this review, we provide the theoretical …

MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO

L Ichino, BA Boone, L Strauskulage, CJ Harris, G Kaur… - Science, 2021 - science.org
… Here, we describe two Arabidopsis thaliana methyl-CpG–binding domain proteins, MBD5
and MBD6, that are recruited to chromatin by recognition of CG methylation, and redundantly …

[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors

JF Kribelbauer, XJ Lu, R Rohs, RS Mann… - Journal of molecular …, 2020 - Elsevier
… available to measure the impact of methylated DNA on TF binding. By relating position-…
ZFPs, proteins with a canonical methyl-binding domain, and specialized TFs such as p53 […

A group of SUVH methylDNA binding proteins regulate expression of the DNA demethylase ROS1 in Arabidopsis

X Xiao, J Zhang, T Li, X Fu, V Satheesh… - Journal of integrative …, 2019 - Wiley Online Library
domain known to bind methylated DNA, we tested whether the SUVH proteins could bind
SUVH3 could only bind to methylated MEMS (Figure 3C) and the binding was competitively …

Molecular mechanism of methyl-dependent and spatial-specific DNA recognition of c-Jun homodimer

LH Bie, JW Fei, J Gao - Journal of Molecular Modeling, 2021 - Springer
… proteins have structurally distinct DNA-binding domains, they share a common methyl-Arg-…
SRA domain recognizes methylated DNA by flipping 5mC from a hemi-methylated CpG out …

Sensitivity of transcription factors to DNA methylation

É Héberlé, AF Bardet - Essays in biochemistry, 2019 - portlandpress.com
… a DNA-binding domain, a trans-activating domain, which binds other … domain, which regulates
their activity (Figure 1A). TFs … to binding methylated DNA using structural information and a …

Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition

ME Potok, Y Wang, L Xu, Z Zhong, W Liu… - Nature …, 2019 - nature.com
… Although MBD9 contains a methyl-CpG-binding domain, it is predicted not to bind methylated
DNA since it lacks key conserved residues required for mCpG binding 61 . Consistently, …

Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation

S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
… an MBD-like domain, also known as a TAM (TIP5/ARBP/MBD) domain, were … bind methylated
DNA 10,11 . Only four MBD proteins harbor a functional domain that binds methylated DNA