… BRAF V600E pLGG as they had whole chromosome copy number alterations in more than
10 chromosomes, … None of these cases showed a pattern of chromosomal instability similar to …

… Instability (MSI) and chromosomal instability have been described [5] . Chromosomal
instability … Tumors with chromosomal instability have chromosomal gains and losses, with or …

… The chromosomal instability (CIN) pathway, or traditional adenoma to carcinoma sequence,
leads to aneuploidy, oncogene activation, and loss of tumor suppressor genes. While most …

… To investigate how aneuploidy could contribute to tumor growth, we triggered periods of
chromosomal instability (CIN) in human cells and then exposed them to different culture …

… heterogeneity was linked with gene-expression intratumor heterogeneity and with enrichment
… Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 …

… These tumors are enriched with oncogenic BRAF V600E point mutations found in 69% of …
in MSS stages III or IV tumors was associated with shorter patient survival, BRAF V600E did not …

… mutation and often show microsatellite instability (MSI) due to … stable but often show
chromosomal instability (CIN) [9]. The … Ectopic BRAF V600E expression in our CC cell models did …

Chromosomal instability (CIN) is a hallmark of the most aggressive malignancies. Features
of these tumors include complex genomic rearrangements, the presence of mis-segregated …

… Additionally, single-agent vemurafenib was shown to arrest cell proliferation and inhibit
tumor growth in CRC cell lines and xenograft models expressing BRAF V600E mutation, …

… -BRAF V600E (VE1) antibody to detect BRAF V600E mutation … negative BRAF V600E staining
by IHC with anti-BRAF V600E (… anti-BRAF V600E (VE1) antibody with molecular testing for …