Phenolic compounds that cross the blood–brain barrier exert positive health effects as central nervous system antioxidants

D Velásquez-Jiménez, DA Corella-Salazar… - Food & Function, 2021 - pubs.rsc.org
… These are all components of the gut–liver–brain axis, … health effects along the way, in fact,
a phenolic may not strictly require access to the brain, since it can induce indirect health effects

[HTML][HTML] The blood–brain barrier in health and disease: Important unanswered questions

CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
… This “blood–brain barrier” is initiated during angiogenesis via … Blood–brain barrier dysfunction
contributes to pathology in a … regarding the blood–brain barrier in health and disease. …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
… of probiotic-promoted neuroprotective effects in AD studies remain to be determined but
may reflect positive effects on gut barrier health leading to improved immune and metabolic …

Blood-brain barrier permeability and physical exercise

MA Małkiewicz, A Szarmach, A Sabisz… - Journal of …, 2019 - Springer
… numerous beneficial health effects. Epidemiological studies indicate that physical activity
leads to systemic adaptations and an elongated health-span, thus time of life in good health, in …

Healthy aging and the blood–brain barrier

WA Banks, MJ Reed, AF Logsdon, EM Rhea… - Nature aging, 2021 - nature.com
… BM with normal aging affect all components and are specific to each brain region. These
changes are likely to have effects on local microvascular function that impact the normal …

[HTML][HTML] Blood–brain barrier dynamics to maintain brain homeostasis

M Segarra, MR Aburto, A Acker-Palmer - Trends in neurosciences, 2021 - cell.com
… The blood–brain barrier (BBB) is a dynamic platform for exchange of substances between
the blood and the brain parenchyma, and it is an essential functional gatekeeper for the …

The blood-brain barrier in aging and neurodegeneration

EG Knox, MR Aburto, G Clarke, JF Cryan… - Molecular …, 2022 - nature.com
… This barrier, however, breaks down with age and further disruption … barrier, and discuss
current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects

Regulation of blood–brain barrier integrity by microglia in health and disease: a therapeutic opportunity

PT Ronaldson, TP Davis - Journal of Cerebral Blood Flow & …, 2020 - journals.sagepub.com
… Such activation correlates with dysfunction of the blood–brain barrier (BBB), which is an
early event in stroke 3 and Alzheimer’s disease. In this review, we will discuss direct effects of …

Increase in blood–brain barrier leakage in healthy, older adults

ICM Verheggen, JJA de Jong, MPJ van Boxtel… - Geroscience, 2020 - Springer
Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

X Huang, B Hussain, J Chang - CNS neuroscience & …, 2021 - Wiley Online Library
… The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …