Background The spectrum of BRCA1 and BRCA2 mutations in Slavic countries is characterized
by a high prevalence of founder alleles. Methods We analyzed a large data set of …

… have found two founder mutations in BRCA1 gene in Middle Eastern population, we cannot
rule out the possibility that other founder mutations in BRCA1 and/or BRCA2 genes may also …

… This study aimed to evaluate the prevalence and spectrum of 13 BRCA1 and BRCA2 founder
mutations most frequently observed in the area of Central Europe in unselected patients …

… In this study, LOH was observed in 91 and 67% of ovarian tumors with a BRCA1 and BRCA2
germline pathogenic mutation, respectively, which is in accordance with previous reports. …

… , mostly BRCA1/BRCA2 genes. Because genetic predispositions vary by ethnicity, several
studies have reported founder variants of BRCA1/BRCA2 genes. Such founder variants were …

… : BRCA1 and BRCA2 are high-penetrance inherited genes; different founder mutations have
been … L63X mutation, other BRCA1 mutations, and BRCA2 mutations using Chi-square test. …

… We have already taken advantage of these findings by testing patients from Crete for the
reported founder mutations, before sequencing the whole genes, since genetic services are …

… , a de novo mutation or a mutation present in a founding member can become widespread in
… Population genetic testing for cancer susceptibility: founder mutations to genomes. Nat Rev …

… are BRCA1 185delAG, 5382insC and BRCA2 6174delT,5, 6 the three founder mutations …
.7, 8 Other founder mutations have also been reported in Iceland (BRCA2 c.771_775del),9 the …

… A>T could be considered to be a founder mutation in this ovarian cancer population. This
recurrent BRCA1 mutation has rarely been observed in other ethnic groups. Our findings are …