… drugs have become mainstream cancer treatments. Since the … have been developed
for the treatment of malignancies. By … Despite great progress, small-molecule targeted anti-cancer …

… The identification of molecular targets and … cancer treatment. Both multitargeted and highly
selective kinase inhibitors are used for the treatment of advanced treatment-resistant cancers, …

… defined in terms of the targets involved in targeted therapy. … for several types of cancer
treatment include their low response rate … to enhance the efficacy of cytokines in cancer treatment: …

… Unique validated … for targets with approved or preclinical cancer compounds), providing
a dataset of synthetic-lethality evidence for the association between 623 genes and 19 cancer …

… clinically validated treatment for many cancers to … cancer and stromal cells. Their altered
expression in malignancies dictates leukocyte recruitment and activation, angiogenesis, cancer …

… Here we experimentally validate the one–two punch therapy for treatment of liver … inhibitors
and the degree of inhibition of the downstream targets of CDC7. To further address why it is …

… the current TNBC treatment options, unmet clinical needs, and actionable drug targets,
including … Supported by strong evidence in developmental, evolutionary, and cancer biology, we …

… targets, and secondary resistance, mostly driven by adaptation of the cancer cell to the
selection pressure of treatment. … , clinically validated resistance biomarker to guide treatment …

… them generally accessible drug targets. Early drug discovery … psychiatric diseases to diabetes
and cancer. In this Review, we … at both established and emerging targets. Last, we address …

… Here we analyse the evidence that many cancer targets remain to be discovered using a …
The number of novel druggable targets that have been nominated and fully validated by Project …