… affinity antibody responses. This can be attributed to the complexity of B cell differentiation
and affinity … , which makes these highly specialized cells susceptible to rapid apoptosis ex vivo…

… B-cell to plasma cell differentiation during the germinal center reaction has been shown. To
investigate if antigen affinity-based Tfh cell … model that integrates cellular interactions with a …

… of TCR affinity on differentiation and T cell/DC … T cells with differing TCR affinities for the
same p:MHCII ligand (20). We found that Th cells with low-, medium-, or high-affinity TCR T cells …

… B cells differ in their affinity for antigen throughout … cell receptor affinity for antigen is one of
the important determinants in the cell fate decision for plasma cell and GC B cell differentiation…

… of antigen valency during different phases of B cell responses … activated cognate B cells,
with little affinity discrimination. This … antigen valencies on B cell activation, B cell differentiation, …

… affinity for antigen determines the amount of antigen the cell … both plasma cell differentiation
and GC B-cell expansion. Our … of GC B-cell differentiation into plasma cells or GC cycling by …

… effector T cell differentiation and a holistic view of CD4 + T cell … how Teff and Tfh cells
differentiate from naive precursors, as … differentiation, while those activated by low-affinity antigen …

… Finally, low-affinity or high-affinity peptide ligands for the same TCR can instruct T reg
cell differentiation with equal efficiency provided that the density of the low-affinity ligand is …

… Our investigation of AAM focused on antigen-specific GCB-cell differentiation and selection,
given the reports of active SHM in these models and autoantibodies (6, 21, 51–53). The (4-…

… B cells with higher affinity receptors (BCRs) are selected are not entirely clear. Progeny cells
with higher affinity BCRs … during antigen clearance. Another possibility is that unprocessed …