The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients

BY Wang, JY Huang, HC Chen, CH Lin, SH Lin… - … of cancer research and …, 2020 - Springer
… There were 48,296 non-small cell lung cancer (NSCLC) patients analyzed between 2009 …
In this study, data from 37,463 lung cancer patients were analyzed. 28,980 patients (77.4%) …

… non-comparative phase II study of anti-programmed cell death-ligand 1 atezolizumab or chemotherapy as second-line therapy in patients with small cell lung cancer …

JL Pujol, L Greillier, C Audigier-Valette… - … of Thoracic Oncology, 2019 - Elsevier
… Several patients in our study had sustained disease control. PD-L1 expression on tumor
cells or tumor-infiltrating immune cells did not differ in this subgroup. Next-generation …

Immune cell composition in human non-small cell lung cancer

B Stankovic, HAK Bjørhovde, R Skarshaug… - Frontiers in …, 2019 - frontiersin.org
Lung cancer is the leading cause of cancer-related death worldwide with a high … cell lung
cancer (NSCLC) is the most common type of lung cancers, representing ~90% of all cases (2). …

Immunotherapeutic approaches for small-cell lung cancer

WT Iams, J Porter, L Horn - Nature Reviews Clinical Oncology, 2020 - nature.com
… Various tumour-based and/or blood-based assays have been evaluated for their ability to
predict clinical benefit from immune-checkpoint inhibitors in patients with small-cell lung cancer

Small-cell lung cancer

CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
… SCLC makes up about 15% of lung cancer cases. Patients with SCLC typically present
with respiratory symptoms, including cough, dyspnoea (laboured breathing) or haemoptysis (…

Emerging therapies for small cell lung cancer

S Yang, Z Zhang, Q Wang - Journal of hematology & oncology, 2019 - Springer
… A phase I study to evaluate the safety and clinical activity of durvalumab in … -cell lung cancer
was performed in 2017. In this study, 30 patients in the expansion phase received treatment, …

Comprehensive T cell repertoire characterization of non-small cell lung cancer

A Reuben, J Zhang, SH Chiou, RM Gittelman… - Nature …, 2020 - nature.com
… This requires a better understanding of the T cells in the lungs of patients with NSCLC.
Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T …

Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

XC Zhang, J Wang, GG Shao, Q Wang, X Qu… - Nature …, 2019 - nature.com
patients. Here we report an extensive molecular and immune … study of 245 Chinese patients
with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell

Evolution of systemic therapy for stages I–III non-metastatic non-small-cell lung cancer

JE Chaft, A Rimner, W Weder, CG Azzoli… - … Clinical oncology, 2021 - nature.com
… with early-stage lung cancer has rapidly expanded. In this Review, we … the treatment of
patients with early-stage lung cancer and explore the current and future state of clinical research

Current diagnosis and management of small-cell lung cancer

S Wang, S Zimmermann, K Parikh, AS Mansfield… - Mayo Clinic …, 2019 - Elsevier
… Small-cell lung cancer (SCLC) is an aggressive disease with distinct pathological, clinical,
and molecular characteristics from non–small-cell lung cancer. SCLC has high metastatic …